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    Angiosarcoma treated successfully with anti-PD-1 therapy - a case report

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    s40425-017-0263-0.pdf
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    Author
    Sindhu, Simran
    Gimber, Lana H.
    Cranmer, Lee
    McBride, Ali
    Kraft, Andrew S.
    Affiliation
    Univ Arizona, Div Hematol Oncol, Dept Med
    Univ Arizona, Dept Med Imaging
    Univ Arizona, Ctr Canc
    Issue Date
    2017-07-18
    
    Metadata
    Show full item record
    Publisher
    BIOMED CENTRAL LTD
    Citation
    Angiosarcoma treated successfully with anti-PD-1 therapy - a case report 2017, 5 (1) Journal for ImmunoTherapy of Cancer
    Journal
    Journal for ImmunoTherapy of Cancer
    Rights
    © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Background: Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in all age groups, but are more common in older patients; with the cutaneous form most common in older white men. Combined modality therapy including surgery and radiation appears to have a better outcome than each modality alone. When metastatic, agents such as liposomal doxorubicin, paclitaxel and ifosfamide have activity but it is short-lived and not curative. Immunotherapy targeting either the PD-1 receptor or PD-L1 ligand has recently been shown to have activity in multiple cancers including melanoma, renal, and non-small lung cancer. Although these agents have been used in sarcoma therapy, their ability to treat angiosarcoma has not been reported. Case presentation: Here we describe the case of a 63-year-old man who presented initially with angiosarcoma of the nose and received surgery for the primary. Over 4 years he had recurrent disease in the face and liver and was treated with nab-paclitaxel, surgery, and radioembolization, but continued to have progressive disease. His tumor was found to express PD-L1 and he received off- label pembrolizumab 2 mg/kg every 21 days for 13 cycles with marked shrinkage of his liver disease and no new facial lesions. Secondary to this therapy he developed hepatitis and has been treated with decreasing doses of prednisone. During the 8 months off therapy he has developed no new or progressive lesions. Conclusions: Although occasional responses to immunotherapy have been reported for sarcomas, this case report demonstrates that angiosarcoma can express PD-L1 and have a sustained response to PD-1 directed therapy.
    ISSN
    2051-1426
    DOI
    10.1186/s40425-017-0263-0
    Version
    Final published version
    Sponsors
    NCI (University of Arizona Cancer Center Support Grant) [5P30 CA023074]
    Additional Links
    http://jitc.biomedcentral.com/articles/10.1186/s40425-017-0263-0
    ae974a485f413a2113503eed53cd6c53
    10.1186/s40425-017-0263-0
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