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    Endoscope Design for Volume Holographic Imaging

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    Author
    Howlett, Isela Danielle
    Issue Date
    2017
    Keywords
    Endoscopy
    Holography
    Optics
    Advisor
    Kostuk, Raymond K.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Early stage detection of cancerous tissue is critical to increasing the 5-year survival rate for patients. The development of devices capable of accessing and visualizing these tissue sites plays an important role in this process. Many cancer types have existing screening methods however many have proven ineffective in large clinical trials. Since early stages of cancer development often has subtle changes from normal tissue, traditional non-invasive imaging techniques such as ultrasound or magnetic resonance imaging are not able to detect them. The following work evaluates the feasibility of miniaturization of Volume Holographic Imaging (VHI) systems into laparoscopic endoscopes for tissue and cancer screening. The work is divided into two main sections discussing the design and evaluation of each imaging system. The first system is a Reflectance VHI Endoscope designed for simultaneous imaging of two imaging depths within a tissue sample. The system is evaluated for resolution and contrast through imaging of resolution bar targets and soft tissue samples. The second system is a Wavelength Coded VHI Endoscope which combines the Reflectance VHI Endoscope imaging properties with axial chromatic dispersion effects of Gradient Index (GRIN) optics to improve the volume holographic element performance and reduce excess background light. Both Reflectance and Wavelength Coded VHI systems utilize a sub-4 mm diameter rigid relay probe which has been approved for in-vivo applications. The sub-4.4 µm/lp resolution produced by both VHI Endoscope systems and tissue depth separations of 50 µm and 100 µm for the Reflectance and Wavelength Coded designs, respectively, make VHI systems a candidate for clinical evaluation of early stage cancer development.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Optical Sciences
    Degree Grantor
    University of Arizona
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