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    Cytoarchitectonically-Driven MRI Atlas of the Hippocampus and the Behavioral Impact of Neural Recording Devices: Addressing Methodological Concerns for Studies of Age-Related Change in Hippocampal Subfields

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    Author
    Kyle, Colin T.
    Issue Date
    2017
    Keywords
    aging
    CA1
    CA3
    DG
    hippocampus
    MRI
    Advisor
    Barnes, Carol A.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The hippocampal formation forms a circuit of cytoarchitectonically distinct subregions, and substantial evidence suggests each region makes unique computational contributions that support spatial and episodic memory. With aging, hippocampal subfields undergo unique neurobiological alterations, and primate in vivo work making use of both MR imaging and chronic neural recording devices has important links to changes seen in nonprimate animal models with aging (Thome et al., 2016; Yassa et al., 2011a; Yassa et al., 2010). While MRI offers a noninvasive way to study the hippocampal subfields, identifying hippocampal subregions without using post mortem histology is a challenge. When different research labs attempted to identify the hippocampal subregions using a single subject’s MRI, researchers showed significant disagreement in where to label different subregions (Yushkevich et al., 2015a). Alternatively, chronic neural recording devices offer an invasive solution to studying hippocampal subfields. However, it is currently not clear whether the mechanical trauma and foreign body response produced by neural recording devices disrupts neural circuits critical for behavior. Here, my colleagues and I address these issues with in vivo primate research. Chapter I provides a general introduction to the hippocampal circuits and changes observed in aging. Chapter II presents novel methods for construction of a histology-driven MRI atlas of nonhuman primate hippocampus that addresses accurate identification of hippocampal subfields in MR images. Chapter III presents empirical work that examines whether chronic neural recording devices targeted at the hippocampus affect recognition memory. Finally, Chapter IV provides a general discussion of both works in the context of the broader literature.
    Type
    text
    Electronic Thesis
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Neuroscience
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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