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    Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex

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    Author
    Maurer, Andrew P. cc
    Burke, Sara N. cc
    Diba, Kamran cc
    Barnes, Carol A. cc
    Affiliation
    Univ Arizona, Evelyn F McKnight Brain Inst
    Univ Arizona, Div Neural Syst Memory & Aging
    Univ Arizona, Dept Psychol
    Univ Arizona, Dept Neurol
    Univ Arizona, Dept Neurosci
    Issue Date
    2017-09-13
    Keywords
    hippocampus
    medial temporal lobe
    object field
    place field
    rat
    
    Metadata
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    Publisher
    SOC NEUROSCIENCE
    Citation
    Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex 2017, 37 (37):8965 The Journal of Neuroscience
    Journal
    The Journal of Neuroscience
    Rights
    Copyright © 2017 the authors.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The perirhinal cortex (PER), which is critical for associative memory and stimulus discrimination, has been described as a wall of inhibition between the neocortex and hippocampus. With advanced age, rats show deficits on PER-dependent behavioral tasks and fewer PER principal neurons are activated by stimuli, but the role of PER interneurons in these altered circuit properties in old age has not been characterized. In the present study, PER neurons were recorded while rats traversed a circular track bidirectionally in which the track was either empty or contained eight novel objects evenly spaced around the track. Putative interneurons were discriminated from principal cells based on the autocorrelogram, waveform parameters, and firing rate. While object modulation of interneuron firing was observed in both young and aged rats, PER interneurons recorded from old animals had lower firing rates compared with those from young animals. This difference could not be accounted for by differences in running speed, as the firing rates of PER interneurons did not show significant velocity modulation. Finally, in the aged rats, relative to young rats, there was a significant reduction in detected excitatory and inhibitory monosynaptic connections. Together these data suggest that with advanced age there may be reduced afferent drive from excitatory cells onto interneurons that may compromise the wall of inhibition between the hippocampus and cortex. This circuit dysfunction could erode the function of temporal lobe networks and ultimately contribute to cognitive aging.
    Note
    6 month embargo; Published: 13 September 2017.
    ISSN
    0270-6474
    1529-2401
    PubMed ID
    28821661
    DOI
    10.1523/JNEUROSCI.0531-17.2017
    Version
    Final published version
    Sponsors
    McKnight Brain Research Foundation; National Institutes of Health [AG003376, NS054465, NS070464, AG049722, AG049411, AG055544, MH109548]
    Additional Links
    http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0531-17.2017
    ae974a485f413a2113503eed53cd6c53
    10.1523/JNEUROSCI.0531-17.2017
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