Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex
Affiliation
Univ Arizona, Evelyn F McKnight Brain InstUniv Arizona, Div Neural Syst Memory & Aging
Univ Arizona, Dept Psychol
Univ Arizona, Dept Neurol
Univ Arizona, Dept Neurosci
Issue Date
2017-09-13
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SOC NEUROSCIENCECitation
Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex 2017, 37 (37):8965 The Journal of NeuroscienceJournal
The Journal of NeuroscienceRights
Copyright © 2017 the authors.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The perirhinal cortex (PER), which is critical for associative memory and stimulus discrimination, has been described as a wall of inhibition between the neocortex and hippocampus. With advanced age, rats show deficits on PER-dependent behavioral tasks and fewer PER principal neurons are activated by stimuli, but the role of PER interneurons in these altered circuit properties in old age has not been characterized. In the present study, PER neurons were recorded while rats traversed a circular track bidirectionally in which the track was either empty or contained eight novel objects evenly spaced around the track. Putative interneurons were discriminated from principal cells based on the autocorrelogram, waveform parameters, and firing rate. While object modulation of interneuron firing was observed in both young and aged rats, PER interneurons recorded from old animals had lower firing rates compared with those from young animals. This difference could not be accounted for by differences in running speed, as the firing rates of PER interneurons did not show significant velocity modulation. Finally, in the aged rats, relative to young rats, there was a significant reduction in detected excitatory and inhibitory monosynaptic connections. Together these data suggest that with advanced age there may be reduced afferent drive from excitatory cells onto interneurons that may compromise the wall of inhibition between the hippocampus and cortex. This circuit dysfunction could erode the function of temporal lobe networks and ultimately contribute to cognitive aging.Note
6 month embargo; Published: 13 September 2017.ISSN
0270-64741529-2401
PubMed ID
28821661Version
Final published versionSponsors
McKnight Brain Research Foundation; National Institutes of Health [AG003376, NS054465, NS070464, AG049722, AG049411, AG055544, MH109548]Additional Links
http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0531-17.2017ae974a485f413a2113503eed53cd6c53
10.1523/JNEUROSCI.0531-17.2017
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