A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock
Tran, Phat L.
Pilikian, Tia R.
Marsh, Katie M.
Khalpey, Zain I.
AffiliationUniv Arizona, Dept Surg, Div Cardiothorac Surg
Univ Arizona, Coll Med
Univ Arizona, Dept Physiol Sci
Univ Arizona, Dept Biomed Engn
Left Ventricular Assist Device (LVAD)
Refractory Cardiogenic Shock (RCS)
Amniotic stem cell
MetadataShow full item record
PublisherBIOMED CENTRAL LTD
CitationA dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock 2017, 12 (1) Journal of Cardiothoracic Surgery
Rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground: Temporary mechanical circulatory support device without sternotomy has been highly advocated for severe cardiogenic shock patient but little is known when coupled with amniotic stem cell therapy. Case presentation: This case reports the first dual therapy of temporary left ventricular extracorporeal device CentriMag with distal banding technique and human amniotic stem cell injection for treating a severe refractory cardiogenic shock of an 68-year-old female patient. A minimally-invasive off-pump LVAD was established by draining from the left ventricle and returning to the right axillary artery with distal arterial banding to prevent right upper extremity hyperperfusion. Amniotic stem cells were injected intramyocardially at the left ventricular apex, lateral wall, inferior wall, and right subclavian vein. Conclusion: The concomitant use of the temporary minimally-invasive off-pump CentriMag placement and stem cell therapy not only provided an alternative to cardiopulmonary bypass and full-median sternotomy procedures but may have also synergistically enhanced myocardial reperfusion and regeneration.
VersionFinal published version
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