AuthorSprissler, Ryan Steven
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
EmbargoRelease after 01-Mar-2018
AbstractEpilepsy, characterized primarily by seizures, is one of the most common forms of neurological dysfunction in humans. This dissertation will explore the genetic components and responses to seizures in both animal and human models. This will encompass different forms of seizure etiology including genetically derived channelopathies leading to generalized seizures as well as temporal lobe epilepsy with a wide rage of etiologies. Specific attention is paid to changes in the transcriptional profile of the hippocampus in these various forms of epilepsy before and after seizure activity.
Degree ProgramGraduate College