Affiliation
University of Arizona, Department of PediatricsIssue Date
2017-10
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Published by Wolters Kluwer - MedKnowCitation
Aminophylline-associated hyponatremia in a premature infant 2017, 6 (4):259 Journal of Clinical NeonatologyJournal
Journal of Clinical NeonatologyRights
Copyright © 2017 Journal of Clinical Neonatology. This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Hyponatremia is common in preterm infants. The causes are usually related to the inability of the premature kidneys to excrete a given water load, excessive sodium losses, or inadequate sodium intake. Here, we present a case of severe hyponatremia in an extreme preterm infant, associated with the use of aminophylline. Aminophylline was administered intravenously on day 1 for the treatment of apnea of prematurity. On day 3, the patient developed hyponatremia which was not responsive to sodium replacement and fluid restriction. Due to concerns of aminophylline‑induced hyponatremia, aminophylline was discontinued on day 6, and within 48 h of discontinuation, serum sodium normalized without the need for sodium supplementation. The purpose of the case report is to present a rare complication associated with aminophylline use and to shed light on potential deleterious effects associated with drug shortages.Note
Open Access Article.ISSN
2249-4847Version
Final published versionAdditional Links
http://www.jcnonweb.com/text.asp?2017/6/4/259/216899ae974a485f413a2113503eed53cd6c53
10.4103/jcn.JCN_1_17
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Except where otherwise noted, this item's license is described as Copyright © 2017 Journal of Clinical Neonatology. This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License.