Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs
AuthorMacLean, Evan L.
Gesquiere, Laurence R.
Gruen, Margaret E.
Sherman, Barbara L.
Martin, W. Lance
Carter, C. Sue
AffiliationUniv Arizona, Sch Anthropol
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationEndogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs 2017, 8 Frontiers in Psychology
JournalFrontiers in Psychology
Rights© 2017 MacLean, Gesquiere, Gruen, Sherman, Martin and Carter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractAggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)-neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species-and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma. In Experiment 1 we evaluated behavioral and neuroendocrine differences between a population of pet dogs with a history of chronic aggression toward conspecifics and a matched control group. Dogs with a history of aggression exhibited more aggressive behavior during simulated encounters with conspecifics, and had lower free, but higher total plasma AVP than matched controls, but there were no group differences for OT. In Experiment 2 we compared OT and AVP concentrations between pet dogs and a population of assistance dogs that have been bred for affiliative and non-aggressive temperaments, and investigated neuroendocrine predictors of individual differences in social behavior within the assistance dog population. Compared to pet dogs, assistance dogs had higher free and total OT, but there were no differences in either measure for AVP. Within the assistance dog population, dogs who behaved more aggressively toward a threatening stranger had higher total AVP than dogs who did not. Collectively these data suggest that endogenous OT and AVP may play critical roles in shaping dog social behavior, including aspects of both affiliation and aggression.
NoteOpen access journal.
UA Open Access Publishing Fund.
VersionFinal published version
SponsorsClinical Services Core at North Carolina State University College of Veterinary Medicine; Fetzer Foundation; NIH [P01 HD 075750]
CollectionsUA Faculty Publications
- Effects of Affiliative Human-Animal Interaction on Dog Salivary and Plasma Oxytocin and Vasopressin.
- Authors: MacLean EL, Gesquiere LR, Gee NR, Levy K, Martin WL, Carter CS
- Issue date: 2017
- Validation of salivary oxytocin and vasopressin as biomarkers in domestic dogs.
- Authors: MacLean EL, Gesquiere LR, Gee N, Levy K, Martin WL, Carter CS
- Issue date: 2018 Jan 1
- Early involvement in friendships predicts later plasma concentrations of oxytocin and vasopressin in juvenile rhesus macaques (Macaca mulatta).
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- Issue date: 2014
- Neuropeptide regulation of social behavior in a monogamous cichlid fish.
- Authors: Oldfield RG, Hofmann HA
- Issue date: 2011 Mar 1
- Oxytocin and vasopressin modulate the social response to threat: a preclinical study.
- Authors: Bowen MT, McGregor IS
- Issue date: 2014 Oct