Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions
Arce, Fernando Teran
Sirbuly, Donald J.
AffiliationUniv Arizona, Coll Med, Div Translat & Regenerat Med
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationNanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions 2017, 11 (6):352 Nature Photonics
Rights© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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AbstractUltrasensitive nanomechanical instruments, including the atomic force microscope (AFM)(1-4) and optical and magnetic tweezers(5-8), have helped shed new light on the complex mechanical environments of biological processes. However, it is difficult to scale down the size of these instruments due to their feedback mechanisms9, which, if overcome, would enable high-density nanomechanical probing inside materials. A variety of molecular force probes including mechanophores(10), quantum dots(11), fluorescent pairs(12,13) and molecular rotors(14-16) have been designed to measure intracellular stresses; however, fluorescence-based techniques can have short operating times due to photo-instability and it is still challenging to quantify the forces with high spatial and mechanical resolution. Here, we develop a compact nanofibre optic force transducer (NOFT) that utilizes strong near-field plasmon-dielectric interactions to measure local forces with a sensitivity of <200 fN. The NOFT system is tested by monitoring bacterial motion and heart-cell beating as well as detecting infrasound power in solution.
Note6 month embargo; Published online: 15 May 2017
VersionFinal accepted manuscript
SponsorsNational Science Foundation [ECCS 1150952, ECCS-1542148]; University of California, Office of the President [UC-LFRP 12-LR-238415]; California Institute of Regenerative Medicine [RT3-07899]; National Institutes of Health [R01EB021857]; National Institute on Aging of National Institutes of Health [AG028709]