Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions
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Final Accepted Manuscript
Author
Huang, QianLee, Joon

Arce, Fernando Teran
Yoon, Ilsun
Angsantikul, Pavimol
Liu, Justin
Shi, Yuesong
Villanueva, Josh
Thamphiwatana, Soracha
Ma, Xuanyi
Zhang, Liangfang

Chen, Shaochen
Lal, Ratnesh
Sirbuly, Donald J.

Affiliation
Univ Arizona, Coll Med, Div Translat & Regenerat MedIssue Date
2017-05-15
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NATURE PUBLISHING GROUPCitation
Nanofibre optic force transducers with sub-piconewton resolution via near-field plasmon–dielectric interactions 2017, 11 (6):352 Nature PhotonicsJournal
Nature PhotonicsRights
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Ultrasensitive nanomechanical instruments, including the atomic force microscope (AFM)(1-4) and optical and magnetic tweezers(5-8), have helped shed new light on the complex mechanical environments of biological processes. However, it is difficult to scale down the size of these instruments due to their feedback mechanisms9, which, if overcome, would enable high-density nanomechanical probing inside materials. A variety of molecular force probes including mechanophores(10), quantum dots(11), fluorescent pairs(12,13) and molecular rotors(14-16) have been designed to measure intracellular stresses; however, fluorescence-based techniques can have short operating times due to photo-instability and it is still challenging to quantify the forces with high spatial and mechanical resolution. Here, we develop a compact nanofibre optic force transducer (NOFT) that utilizes strong near-field plasmon-dielectric interactions to measure local forces with a sensitivity of <200 fN. The NOFT system is tested by monitoring bacterial motion and heart-cell beating as well as detecting infrasound power in solution.Note
6 month embargo; Published online: 15 May 2017ISSN
1749-48851749-4893
Version
Final accepted manuscriptSponsors
National Science Foundation [ECCS 1150952, ECCS-1542148]; University of California, Office of the President [UC-LFRP 12-LR-238415]; California Institute of Regenerative Medicine [RT3-07899]; National Institutes of Health [R01EB021857]; National Institute on Aging of National Institutes of Health [AG028709]Additional Links
http://www.nature.com/doifinder/10.1038/nphoton.2017.74ae974a485f413a2113503eed53cd6c53
10.1038/nphoton.2017.74