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    Structural Control of Microvessel Diameters: Origins of Metabolic Signals

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    Author
    Reglin, Bettina
    Secomb, Timothy W.
    Pries, Axel R.
    Affiliation
    Univ Arizona, Dept Physiol
    Issue Date
    2017-10-24
    Keywords
    blood flow
    microcirculation
    oxygen transport
    structural adaptation
    vascular remodeling
    
    Metadata
    Show full item record
    Publisher
    FRONTIERS MEDIA SA
    Citation
    Structural Control of Microvessel Diameters: Origins of Metabolic Signals 2017, 8 Frontiers in Physiology
    Journal
    Frontiers in Physiology
    Rights
    © 2017 Reglin, Secomb and Pries. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Diameters of microvessels undergo continuous structural adaptation in response to hemodynamic and metabolic stimuli. To ensure adequate flow distribution, metabolic responses are needed to increase diameters of vessels feeding poorly perfused regions. Possible modes of metabolic control include release of signaling substances from vessel walls, from the supplied tissue and from red blood cells (RBC). Here, a theoretical model was used to compare the abilities of these metabolic control modes to provide adequate tissue oxygenation, and to generate blood flow velocities in agreement with experimental observations. Structural adaptation of vessel diameters was simulated for an observed mesenteric network structure in the rat with 576 vessel segments. For each mode of metabolic control, resulting distributions of oxygen and deviations between simulated and experimentally observed flow velocities were analyzed. It was found that wall-derived and tissue-derived growth signals released in response to low oxygen levels could ensure adequate oxygen supply, but RBC-derived signals caused inefficient oxygenation. Closest agreement between predicted and observed flow velocities was obtained with wall-derived growth signals proportional to vessel length. Adaptation in response to oxygen-independent release of a metabolic signal substance from vessel walls or the supplied tissue was also shown to be effective for ensuring tissue oxygenation due to a dilution effect if growth signal substances are released into the blood. The present results suggest that metabolic signals responsible for structural adaptation of microvessel diameters are derived from vessel walls or from perivascular tissue.
    ISSN
    1664-042X
    DOI
    10.3389/fphys.2017.00813
    Version
    Final published version
    Sponsors
    National Institutes of Health [HL034555]; Schuchtermann-Foundation (Germany, Dortmund)
    Additional Links
    http://journal.frontiersin.org/article/10.3389/fphys.2017.00813/full
    ae974a485f413a2113503eed53cd6c53
    10.3389/fphys.2017.00813
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