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    Ovarian cancer study dropouts had worse health-related quality of life and psychosocial symptoms at baseline and over time

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    AOCS_PRO_dropout_Manuscript_26 ...
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    Description:
    Final Accepted Manuscript
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    Author
    Mercieca-Bebber, Rebecca L
    Price, Melanie A
    Bell, Melanie L
    King, Madeleine T
    Webb, Penelope M
    Butow, Phyllis N
    Affiliation
    Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth
    Issue Date
    2017-10
    Keywords
    depression
    ovarian neoplasms
    patient outcome assessment
    quality of life
    
    Metadata
    Show full item record
    Publisher
    WILEY
    Citation
    Ovarian cancer study dropouts had worse health-related quality of life and psychosocial symptoms at baseline and over time 2017, 13 (5):e381 Asia-Pacific Journal of Clinical Oncology
    Journal
    Asia-Pacific Journal of Clinical Oncology
    Rights
    © 2016 John Wiley & Sons Australia, Ltd
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    AimsParticipant drop out is a major barrier to high-quality patient-reported outcome (PRO) data analysis in cancer research as patients with worsening health are more likely to dropout. To test the hypothesis that ovarian cancer patients with worse PROs would drop out earlier, we examined how patients differed by time of dropout on health-related quality of life (HRQOL), anxiety, depression, optimism and insomnia. MethodsThis analysis included 619 participants, stratified by time of dropout, from the Australian Ovarian Cancer Study - Quality of Life substudy, in which participants completed PRO questionnaires at three-monthly intervals for 21 months. Trends in PROs over time were examined. Pearson correlations examined the relationship between time of dropout and baseline PROs. Multiple linear regression models including age, disease stage and time since diagnosis examined relationships between baseline and final PRO scores, and final PRO scores and dropout group. ResultsParticipants who dropped out earlier had significantly worse baseline HRQOL (p<0.0001) and higher depression (p<0.0001). For all five PROs, final scores were significantly associated with baseline scores (p<0.0001). Time of dropout was significantly associated with final HRQOL (p=0.003), anxiety (p=0.05), depression (p=0.02) and optimism (p=0.02) scores. Depression, HRQOL and anxiety worsened at a faster rate overtime in dropouts than study completers. ConclusionsPoorer HRQOL and higher depression at baseline, and final HRQOL, anxiety, depression and optimism scores were predictive of time of dropout. These results highlight the importance of collecting auxiliary data to inform careful and considered handling of missing PRO data during analysis, interpretation and reporting.
    Note
    12 month embargo; published online: 30 August 2016
    ISSN
    17437555
    PubMed ID
    27573704
    DOI
    10.1111/ajco.12580
    Version
    Final accepted manuscript
    Sponsors
    Cancer Council of New South Wales [RG 36/05]; Cancer Council of Queensland [RG 36/05]; U.S. Army Medical Research and Materiel Command [DAMD17-01-1-0729]; National Health and Medical Research Council (NHMRC) [400413, 400281, 199600]; Cancer Council of New South Wales; Cancer Council of Queensland; Cancer Council of South Australia; Cancer Council of Tasmania; Cancer Council of Victoria; Cancer Council of Western Australia; Sydney Catalyst; Cancer Institute New South Wales; Australian Government, courtesy of Cancer Australia; Australian Government through NHMRC
    Additional Links
    http://doi.wiley.com/10.1111/ajco.12580
    ae974a485f413a2113503eed53cd6c53
    10.1111/ajco.12580
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