Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging
Harriss, Bethany I.
Matsunaga, Terry O.
AffiliationUniv Arizona, Dept Med Imaging
KeywordsPhase-change contrast agent
Multispectral optoacoustic tomography (MSOT)
MetadataShow full item record
PublisherELSEVIER GMBH, URBAN & FISCHER VERLAG
CitationOptically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging 2017, 6:26 Photoacoustics
Rights© 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license.
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AbstractWe demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. (C) 2017 The Authors. Published by Elsevier GmbH.
NoteOpen access journal.
VersionFinal published version
SponsorsImperial College-China Scholarship Council (CSC) scholarship; Cancer Research UK Multi-Disciplinary Project [C53470/A22353]; Cancer Research UK Cancer Imaging Centre at the Institute of Cancer Research; Engineering and Physical Sciences Research Council Strategic Equipment Grant [EP/N015266/1]; National Institutes of Health Grant [CA185684]