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dc.contributor.authorLin, Shengtao
dc.contributor.authorShah, Anant
dc.contributor.authorHernández-Gil, Javier
dc.contributor.authorStanziola, Antonio
dc.contributor.authorHarriss, Bethany I.
dc.contributor.authorMatsunaga, Terry O.
dc.contributor.authorLong, Nicholas
dc.contributor.authorBamber, Jeffrey
dc.contributor.authorTang, Meng-Xing
dc.date.accessioned2017-12-21T19:30:55Z
dc.date.available2017-12-21T19:30:55Z
dc.date.issued2017-06
dc.identifier.citationOptically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging 2017, 6:26 Photoacousticsen
dc.identifier.issn22135979
dc.identifier.pmid28507898
dc.identifier.doi10.1016/j.pacs.2017.04.001
dc.identifier.urihttp://hdl.handle.net/10150/626294
dc.description.abstractWe demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. (C) 2017 The Authors. Published by Elsevier GmbH.
dc.description.sponsorshipImperial College-China Scholarship Council (CSC) scholarship; Cancer Research UK Multi-Disciplinary Project [C53470/A22353]; Cancer Research UK Cancer Imaging Centre at the Institute of Cancer Research; Engineering and Physical Sciences Research Council Strategic Equipment Grant [EP/N015266/1]; National Institutes of Health Grant [CA185684]en
dc.language.isoenen
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAGen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S2213597916300593en
dc.rights© 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license.en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPhase-change contrast agenten
dc.subjectDropleten
dc.subjectMicrobubbleen
dc.subjectUltrasounden
dc.subjectPhotoacousticen
dc.subjectOptical/acoustic vaporisationen
dc.subjectMultispectral optoacoustic tomography (MSOT)en
dc.titleOptically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imagingen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Med Imagingen
dc.identifier.journalPhotoacousticsen
dc.description.noteOpen access journal.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-07-17T23:45:36Z
html.description.abstractWe demonstrate a versatile phase-change sub-micron contrast agent providing three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This agent, which we name 'Cy-droplet', has the following novel features. It comprises a highly volatile perfluorocarbon for easy versatile activation, and a near-infrared optically absorbing dye chosen to absorb light at a wavelength with good tissue penetration. It is manufactured via a 'microbubble condensation' method. The phase-transition of Cy-droplets can be optically triggered by pulsed-laser illumination, inducing photoacoustic signal and forming stable gas bubbles that are visible with echo-ultrasound in situ. Alternatively, Cy-droplets can be converted to microbubble contrast agents upon acoustic activation with clinical ultrasound. Potentially all modes offer extravascular contrast enhancement because of the sub-micron initial size. Such versatility of acoustic and optical 'triggerability' can potentially improve multi-modality imaging, molecularly targeted imaging and controlled drug release. (C) 2017 The Authors. Published by Elsevier GmbH.


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© 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license.
Except where otherwise noted, this item's license is described as © 2017 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license.