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dc.contributor.authorBajaj, Sahil
dc.contributor.authorVanuk, John R.
dc.contributor.authorSmith, Ryan
dc.contributor.authorDailey, Natalie S.
dc.contributor.authorKillgore, William D. S.
dc.date.accessioned2017-12-21T19:37:03Z
dc.date.available2017-12-21T19:37:03Z
dc.date.issued2017-11-22
dc.identifier.citationBlue-Light Therapy following Mild Traumatic Brain Injury: Effects on White Matter Water Diffusion in the Brain 2017, 8 Frontiers in Neurologyen
dc.identifier.issn1664-2295
dc.identifier.doi10.3389/fneur.2017.00616
dc.identifier.urihttp://hdl.handle.net/10150/626295
dc.description.abstractMild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i.e., isotropic diffusion) and anisotropic fashion (i.e., quantitative anisotropy, QA) for fibers crossing 11 brain areas known to be significantly affected following mTBI. Specifically, we investigated how 6 weeks of daily morning blue light exposure therapy (compared to an amber-light placebo condition) impacted changes in white matter diffusion in individuals with mTBI. We observed a significant impact of the blue light treatment (relative to the placebo) on the amount of water diffusion (QA) for multiple brain areas, including the corpus callosum, anterior corona radiata, and thalamus. Moreover, many of these changes were associated with improvements in sleep latency and delayed memory. These findings suggest that blue wavelength light exposure may serve as one of the potential non-pharmacological treatments for facilitating structural and functional recovery following mTBI; they also support the use of QA as a reliable neuro-biomarker for mTBI therapies.
dc.description.sponsorshipU.S. Army Medical Research and Materiel Command [W81XWH-11-1-0056]en
dc.language.isoenen
dc.publisherFRONTIERS MEDIA SAen
dc.relation.urlhttp://journal.frontiersin.org/article/10.3389/fneur.2017.00616/fullen
dc.rights© 2017 Bajaj, Vanuk, Smith, Dailey and Killgore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).en
dc.subjectconcussionen
dc.subjectdiffusion tensor imagingen
dc.subjectfractional isotropyen
dc.subjectisotropic diffusionen
dc.subjectneuropsychological functionen
dc.subjectquantitative anisotropyen
dc.subjectsleepen
dc.subjectstructural recoveryen
dc.titleBlue-Light Therapy following Mild Traumatic Brain Injury: Effects on White Matter Water Diffusion in the Brainen
dc.typeArticleen
dc.contributor.departmentUniv Arizona, Dept Psychiat, Coll Med, SCAN Laben
dc.identifier.journalFrontiers in Neurologyen
dc.description.noteOpen access journal.en
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-04-12T11:47:12Z
html.description.abstractMild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i.e., isotropic diffusion) and anisotropic fashion (i.e., quantitative anisotropy, QA) for fibers crossing 11 brain areas known to be significantly affected following mTBI. Specifically, we investigated how 6 weeks of daily morning blue light exposure therapy (compared to an amber-light placebo condition) impacted changes in white matter diffusion in individuals with mTBI. We observed a significant impact of the blue light treatment (relative to the placebo) on the amount of water diffusion (QA) for multiple brain areas, including the corpus callosum, anterior corona radiata, and thalamus. Moreover, many of these changes were associated with improvements in sleep latency and delayed memory. These findings suggest that blue wavelength light exposure may serve as one of the potential non-pharmacological treatments for facilitating structural and functional recovery following mTBI; they also support the use of QA as a reliable neuro-biomarker for mTBI therapies.


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