• Login
    View Item 
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    •   Home
    • UA Faculty Research
    • UA Faculty Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    journal.pone.0189315.pdf
    Size:
    4.816Mb
    Format:
    PDF
    Description:
    Final Published Version
    Download
    Author
    Tripathi, Ranjana
    Sullivan, Ryan
    Fan, Tai-Hwang M.
    Wang, Dong
    Sun, Yao
    Reed, Guy L.
    Gladysheva, Inna P. cc
    Affiliation
    Univ Arizona, Dept Med, Coll Med Phoenix
    Issue Date
    2017-12-14
    
    Metadata
    Show full item record
    Publisher
    PUBLIC LIBRARY SCIENCE
    Citation
    Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy 2017, 12 (12):e0189315 PLOS ONE
    Journal
    PLOS ONE
    Rights
    © 2017 Tripathi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    Dilated cardiomyopathy (DCM) is the major cause of heart failure affecting both women and men. Limited clinical studies show conflicting data in sex-related differences in the progression of dilated cardiomyopathy and heart failure (HF) outcomes. We examined the comparative sex-related progression of cardiomyopathy and the development of HF (at 4, 7, 13 weeks of age) in a well-established, transgenic mouse model of DCM that recapitulates the progressive stages of human HF. By 13 weeks of age, female mice with DCM had more severe left ventricular systolic dysfunction, left ventricular dilation and wall thinning (P< 0.001 for all) than age-matched male mice with DCM. Female mice also had greater lung edema (P< 0.001), cardiac fibrosis (P< 0.01) and pleural effusions, which were not rescued by ovariectomy. By comparison to DCM male mice at 13 weeks, these pathological changes in female mice with DCM, were associated with significant increases in plasma active renin (P< 0.01), angiotensin II (P< 0.01) and aldosterone levels (P< 0.001). In comparison to DCM male mice, DCM female mice also showed differential expression of the natriuretic peptide system with lower corin and higher ANP, BNP and cGMP levels at 13 weeks of age. We conclude, that female mice with experimental DCM have an accelerated progression of cardiomyopathy and HF, which was not corrected by early ovariectomy. These alterations are associated with early renin activation with increased angiotensin II and aldosterone levels, and altered expression of the natriuretic peptide system.
    Note
    Open access journal.
    ISSN
    1932-6203
    DOI
    10.1371/journal.pone.0189315
    Version
    Final published version
    Sponsors
    NIH [HL092750, NS089707, HL115036]; Scientist Development Grant from AHA [14SDG20510068]
    Additional Links
    http://dx.plos.org/10.1371/journal.pone.0189315
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0189315
    Scopus Count
    Collections
    UA Faculty Publications

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.