Emergence of β-Band Oscillations in the Aged Rat Amygdala during Discrimination Learning and Decision Making Tasks
AffiliationUniv Arizona, Evelyn F McKnight Brain Inst
Univ Arizona, Div Neural Syst Memory & Aging
Univ Arizona, Dept Psychol
Univ Arizona, Dept Neurol
Univ Arizona, Dept Neurosci
Keywordsbasolateral complex of the amygdala
reward magnitude discrimination
MetadataShow full item record
CitationEmergence of β-Band Oscillations in the Aged Rat Amygdala during Discrimination Learning and Decision Making Tasks 2017, 4 (5):ENEURO.0245-17.2017 eneuro
RightsCopyright © 2017 Samson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
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AbstractOlder adults tend to use strategies that differ from those used by young adults to solve decision-making tasks. MRI experiments suggest that altered strategy use during aging can be accompanied by a change in extent of activation of a given brain region, inter-hemispheric bilateralization or added brain structures. It has been suggested that these changes reflect compensation for less effective networks to enable optimal performance. One way that communication can be influenced within and between brain networks is through oscillatory events that help structure and synchronize incoming and outgoing information. It is unknown how aging impacts local oscillatory activity within the basolateral complex of the amygdala (BLA). The present study recorded local field potentials (LFPs) and single units in old and young rats during the performance of tasks that involve discrimination learning and probabilistic decision making. Wefound task-and age-specific increases in power selectively within the beta range (15-30 Hz). The increased beta power occurred after lever presses, as old animals reached the goal location. Periods of high-power beta developed over training days in the aged rats, and was greatest in early trials of a session. beta Power was also greater after pressing for the large reward option. These data suggest that aging of BLA networks results in strengthened synchrony of beta oscillations when older animals are learning or deciding between rewards of different size. Whether this increased synchrony reflects the neural basis of a compensatory strategy change of old animals in reward-based decision-making tasks, remains to be verified.
NoteOpen access journal.
VersionFinal published version
SponsorsMcKnight Brain Research Foundation; National Institutes of Health [R01 AG012609]; Canadian Institute of Health Research [SIB171357]