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    Transcriptional Regulation of the Type 1 Interferon Response by a Nuclear Pore Protein.

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    Author
    Aintablian, Haig
    Affiliation
    The University of Arizona College of Medicine - Phoenix
    Issue Date
    2018-03-28
    Keywords
    Transcriptional regulation
    MeSH Subjects
    Interferons
    Allergy and Immunology
    Nuclear Pore
    Proteins
    Interferon Type 1
    Nuclear Pore Complex Proteins
    Mentor
    Gustin, Kurt
    
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    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Collection Information
    This item is part of the College of Medicine - Phoenix Scholarly Projects 2018 collection. For more information, contact the Phoenix Biomedical Campus Library at pbc-library@email.arizona.edu.
    Publisher
    The University of Arizona.
    Abstract
    The type I interferon (IFN) response is an integral immune response for host defense against viruses. When a virus enters a cell, cellular pattern recognition receptors bind to viral structures leading to transcription and synthesis of interferons ultimately resulting in viral clearance (5). More than twenty unique IFN genes have been found in humans. They are typically divided among three classes, simply labeled Type I IFN, Type II IFN, and Type III IFN. Interferons belonging to all three classes are important for fighting viral infections and for the regulation of the immune system. Specifically, the type I interferons are produced when cells recognize viral particles within them. Simply put, this response, which results in the production of IFN- β, is akin to an alarm being sounded, alerting the body to viral invasion. The transcriptional induction of IFN- β requires numerous signaling molecules that converge on the activation pathways of various transcription factors, ultimately leading to the antiviral response. Although well studied, many components of the type I interferon response are still being deciphered.
    Description
    A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
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