Arenavirus infection correlates with lower survival of its natural rodent host in a long-term capture-mark-recapture study
Vanden Broecke, Bram
Sabuni, Christopher A.
Katakweba, Abdul A. S.
Mulungu, Loth S.
de Bellocq, Joëlle Goüy
Massawe, Apia W.
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
MetadataShow full item record
PublisherBIOMED CENTRAL LTD
CitationArenavirus infection correlates with lower survival of its natural rodent host in a long-term capture-mark-recapture study 2018, 11 (1) Parasites & Vectors
JournalParasites & Vectors
Rights© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractBackground: Parasite evolution is hypothesized to select for levels of parasite virulence that maximise transmission success. When host population densities fluctuate, low levels of virulence with limited impact on the host are expected, as this should increase the likelihood of surviving periods of low host density. We examined the effects of Morogoro arenavirus on the survival and recapture probability of multimammate mice (Mastomys natalensis) using a seven-year capture-mark-recapture time series. Mastomys natalensis is the natural host of Morogoro virus and is known for its strong seasonal density fluctuations. Results: Antibody presence was negatively correlated with survival probability (effect size: 5-8% per month depending on season) but positively with recapture probability (effect size: 8%). Conclusions: The small negative correlation between host survival probability and antibody presence suggests that either the virus has a negative effect on host condition, or that hosts with lower survival probability are more likely to obtain Morogoro virus infection, for example due to particular behavioural or immunological traits. The latter hypothesis is supported by the positive correlation between antibody status and recapture probability which suggests that risky behaviour might increase the probability of becoming infected.
VersionFinal published version
SponsorsUniversity of Antwerp [GOA BOF FFB3567]; Antwerp study centre for disease (ASCID) [GOA BOF FFB3567]; INCO-DEV grant [ICA4-CT2002-10050]; German Research Foundation (Focus Programs from Deutsche Forschungsgemeinschaft) [GU 883/3-1, GU 883/3-2]; European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie grant