Role of Lung Clearance Index in the Early Detection of Pulmonary Changes in Children with Sickle Cell Disease

Chaung, Monica

dc.contributor.author	Chaung, Monica
dc.date.accessioned	2018-03-30T18:12:15Z
dc.date.available	2018-03-30T18:12:15Z
dc.date.issued	2018-03-30
dc.identifier.uri	http://hdl.handle.net/10150/627163
dc.description	A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.	en
dc.description.abstract	Pulmonary complications including acute chest syndrome are leading causes of sickle cell disease related morbidity and mortality. Studies have shown that pulmonary changes can be detected during childhood. Spirometry is the current standard for measuring lung function. Growing evidence suggests that lung clearance index (LCI) is as sensitive as spirometry in identifying pulmonary changes in pediatric patients. Our cross-sectional study compared the sensitivity of LCI to spirometry in the detection of early pulmonary changes in children with sickle cell disease. Our results show that LCI significantly correlates to FEV1% predicted (Spearman’s coefficient -0.44, p = 0.003), FVC % predicted (Spearman’s coefficient -0.44, p = 0.006) and FEF25-75 (Spearman’s coefficient -0.49, p <0.001). Using receiver operating characteristic (ROC) curves, LCI was found to be more sensitive than spirometry, but less specific. The data support LCI’s use as a test to screen for pulmonary changes in children with sickle cell disease. Earlier monitoring of lung function will allow for preventative therapies and delayed progression of pulmonary dysfunction.
dc.language.iso	en_US	en
dc.publisher	The University of Arizona.	en_US
dc.rights	Copyright © is held by the author. Digital access to this material is made possible by the College of Medicine - Phoenix, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.	en_US
dc.subject	Pulmonary	en
dc.subject	Lung Clearance Index	en
dc.subject	Children	en
dc.subject.mesh	Anemia, Sickle Cell	en
dc.subject.mesh	Lung	en
dc.subject.mesh	Early Diagnosis	en
dc.subject.mesh	Child	en
dc.subject.mesh	Adolescent	en
dc.subject.mesh	Child, Preschool	en
dc.subject.mesh	Infant	en
dc.title	Role of Lung Clearance Index in the Early Detection of Pulmonary Changes in Children with Sickle Cell Disease	en_US
dc.type	text; Electronic Thesis	en
dc.contributor.department	The University of Arizona College of Medicine - Phoenix	en
dc.description.collectioninformation	This item is part of the College of Medicine - Phoenix Scholarly Projects 2018 collection. For more information, contact the Phoenix Biomedical Campus Library at pbc-library@email.arizona.edu.	en_US
dc.contributor.mentor	Williams, Sophia	en
refterms.dateFOA	2018-08-14T22:50:26Z
html.description.abstract	Pulmonary complications including acute chest syndrome are leading causes of sickle cell disease related morbidity and mortality. Studies have shown that pulmonary changes can be detected during childhood. Spirometry is the current standard for measuring lung function. Growing evidence suggests that lung clearance index (LCI) is as sensitive as spirometry in identifying pulmonary changes in pediatric patients. Our cross-sectional study compared the sensitivity of LCI to spirometry in the detection of early pulmonary changes in children with sickle cell disease. Our results show that LCI significantly correlates to FEV1% predicted (Spearman’s coefficient -0.44, p = 0.003), FVC % predicted (Spearman’s coefficient -0.44, p = 0.006) and FEF25-75 (Spearman’s coefficient -0.49, p <0.001). Using receiver operating characteristic (ROC) curves, LCI was found to be more sensitive than spirometry, but less specific. The data support LCI’s use as a test to screen for pulmonary changes in children with sickle cell disease. Earlier monitoring of lung function will allow for preventative therapies and delayed progression of pulmonary dysfunction.