Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis
AffiliationUniv Arizona, Coll Med Phoenix
Keywordsvitamin D receptor
late cornified envelope genes
MetadataShow full item record
CitationKarrys, A.; Rady, I.; Chamcheu, R.-C.N.; Sabir, M.S.; Mallick, S.; Chamcheu, J.C.; Jurutka, P.W.; Haussler, M.R.; Whitfield, G.K. Bioactive Dietary VDR Ligands Regulate Genes Encoding Biomarkers of Skin Repair That Are Associated with Risk for Psoriasis. Nutrients 2018, 10, 174.
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AbstractTreatment with 1,25-dihydroxyvitamin D-3 (1,25D) improves psoriasis symptoms, possibly by inducing the expression of late cornified envelope (LCE)3 genes involved in skin repair. In psoriasis patients, the majority of whom harbor genomic deletion of LCE3B and LCE3C (LCE3C_LCE3B-del), we propose that certain dietary analogues of 1,25D activate the expression of residual LCE3A/LCE3D/LCE3E genes to compensate for the loss of LCE3B/LCE3C in the deletant genotype. Herein, human keratinocytes (HEKn) homozygous for LCE3C_LCE3B-del were treated with docosahexaenoic acid (DHA) and curcumin, two low-affinity, nutrient ligands for the vitamin D receptor (VDR). DHA and curcumin induce the expression of LCE3A/LCE3D/LCE3E mRNAs at concentrations corresponding to their affinity for VDR. Moreover, immunohistochemical quantitation revealed that the treatment of keratinocytes with DHA or curcumin stimulates LCE3 protein expression, while simultaneously opposing the tumor necrosis factor-alpha (TNF)-signaled phosphorylation of mitogen activated protein (MAP) kinases, p38 and Jun amino-terminal kinase (JNK), thereby overcoming inflammation biomarkers elicited by TNF challenge. Finally, DHA and curcumin modulate two transcription factors relevant to psoriatic inflammation, the activator protein-1 factor Jun B and the nuclear receptor NR4A2/NURR1, that is implicated as a mediator of VDR ligand-triggered gene control. These findings provide insights into the mechanism(s) whereby dietary VDR ligands alter inflammatory and barrier functions relevant to skin repair, and may provide a molecular basis for improved treatments for mild/moderate psoriasis.
VersionFinal published version
SponsorsNIH [DK033351, CA140285]; POHOFI Inc., Pre-College Intern Scholarship Award; American Skin Association (ASA) Carson Research Scholar Award in Psoriasis; UW-Madison Skin Disease Research Center (SDRC) Pilot and Feasibility Research Award from NIH/NIAMS [P30 AR066524]; University of Louisiana at Monroe School of Pharmacy; University of Arizona, Department of Basic Medical Sciences
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- Authors: Hoss E, Austin HR, Batie SF, Jurutka PW, Haussler MR, Whitfield GK
- Issue date: 2013 Dec
- Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin.
- Authors: Austin HR, Hoss E, Batie SF, Moffet EW, Jurutka PW, Haussler MR, Whitfield GK
- Issue date: 2014 Jan 24
- Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.
- Authors: Niehues H, Tsoi LC, van der Krieken DA, Jansen PAM, Oortveld MAW, Rodijk-Olthuis D, van Vlijmen IMJJ, Hendriks WJAJ, Helder RW, Bouwstra JA, van den Bogaard EH, Stuart PE, Nair RP, Elder JT, Zeeuwen PLJM, Schalkwijk J
- Issue date: 2017 Nov
- Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis.
- Authors: de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, Giardina E, Stuart PE, Nair R, Helms C, Escaramís G, Ballana E, Martín-Ezquerra G, den Heijer M, Kamsteeg M, Joosten I, Eichler EE, Lázaro C, Pujol RM, Armengol L, Abecasis G, Elder JT, Novelli G, Armour JA, Kwok PY, Bowcock A, Schalkwijk J, Estivill X
- Issue date: 2009 Feb
- Feasibility of establishing deletion of the late cornified envelope genes LCE3B and LCE3C as a susceptibility factor for psoriasis.
- Authors: Bashir S, Hassan I, Majid S, Bhat YJ, Farooq R
- Issue date: 2016