Mechanistic Insights into Human Brain Impact Dynamics through Modal Analysis
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PhysRevLett.120.138101.pdf
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1.274Mb
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Final Published Version
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AMER PHYSICAL SOCCitation
Laksari, K., Kurt, M., Babaee, H., Kleiven, S., & Camarillo, D. (2018). Mechanistic Insights into Human Brain Impact Dynamics through Modal Analysis. Physical review letters, 120(13), 138101.Journal
PHYSICAL REVIEW LETTERSRights
© 2018 American Physical Society.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Although concussion is one of the greatest health challenges today, our physical understanding of the cause of injury is limited. In this Letter, we simulated football head impacts in a finite element model and extracted the most dominant modal behavior of the brain's deformation. We showed that the brain's deformation is most sensitive in low frequency regimes close to 30 Hz, and discovered that for most subconcussive head impacts, the dynamics of brain deformation is dominated by a single global mode. In this Letter, we show the existence of localized modes and multimodal behavior in the brain as a hyperviscoelastic medium. This dynamical phenomenon leads to strain concentration patterns, particularly in deep brain regions, which is consistent with reported concussion pathology.ISSN
0031-90071079-7114
Version
Final published versionSponsors
Child Health Research Institute through the Thrasher Early Career Award; Lucile Packard Foundation for Children's Health through the Thrasher Early Career Award; Stanford CTSA through the Thrasher Early Career Award [UL1 TR001085]; Thrasher Research Foundation through the Thrasher Early Career Award; National Institutes of Health (NIH) National Institute of Bio-medical Imaging and Bioengineering (NIBIB) [3R21EB01761101S1]Additional Links
https://link.aps.org/doi/10.1103/PhysRevLett.120.138101ae974a485f413a2113503eed53cd6c53
10.1103/PhysRevLett.120.138101