Mechanistic Insights into Human Brain Impact Dynamics through Modal Analysis
AffiliationUniv Arizona, Dept Bioemed Engn
MetadataShow full item record
PublisherAMER PHYSICAL SOC
CitationLaksari, K., Kurt, M., Babaee, H., Kleiven, S., & Camarillo, D. (2018). Mechanistic Insights into Human Brain Impact Dynamics through Modal Analysis. Physical review letters, 120(13), 138101.
JournalPHYSICAL REVIEW LETTERS
Rights© 2018 American Physical Society
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractAlthough concussion is one of the greatest health challenges today, our physical understanding of the cause of injury is limited. In this Letter, we simulated football head impacts in a finite element model and extracted the most dominant modal behavior of the brain's deformation. We showed that the brain's deformation is most sensitive in low frequency regimes close to 30 Hz, and discovered that for most subconcussive head impacts, the dynamics of brain deformation is dominated by a single global mode. In this Letter, we show the existence of localized modes and multimodal behavior in the brain as a hyperviscoelastic medium. This dynamical phenomenon leads to strain concentration patterns, particularly in deep brain regions, which is consistent with reported concussion pathology.
VersionFinal published version
SponsorsChild Health Research Institute through the Thrasher Early Career Award; Lucile Packard Foundation for Children's Health through the Thrasher Early Career Award; Stanford CTSA through the Thrasher Early Career Award [UL1 TR001085]; Thrasher Research Foundation through the Thrasher Early Career Award; National Institutes of Health (NIH) National Institute of Bio-medical Imaging and Bioengineering (NIBIB) [3R21EB01761101S1]