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dc.contributor.authorGarcia, Missael
dc.contributor.authorEdmiston, Christopher
dc.contributor.authorYork, Timothy
dc.contributor.authorMarinov, Radoslav
dc.contributor.authorMondal, Suman
dc.contributor.authorZhu, Nan
dc.contributor.authorSudlow, Gail P.
dc.contributor.authorAkers, Walter J.
dc.contributor.authorMargenthaler, Julie
dc.contributor.authorAchilefu, Samuel
dc.contributor.authorLiang, Rongguang
dc.contributor.authorZayed, Mohamed A.
dc.contributor.authorPepino, Marta Y.
dc.contributor.authorGruev, Viktor
dc.date.accessioned2018-05-24T17:43:22Z
dc.date.available2018-05-24T17:43:22Z
dc.date.issued2018-04-20
dc.identifier.citationMissael Garcia, Christopher Edmiston, Timothy York, Radoslav Marinov, Suman Mondal, Nan Zhu, Gail P. Sudlow, Walter J. Akers, Julie Margenthaler, Samuel Achilefu, Rongguang Liang, Mohamed A. Zayed, Marta Y. Pepino, and Viktor Gruev, "Bio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgery," Optica 5, 413-422 (2018)en_US
dc.identifier.issn2334-2536
dc.identifier.doi10.1364/OPTICA.5.000413
dc.identifier.urihttp://hdl.handle.net/10150/627788
dc.description.abstractImage-guided surgery can enhance cancer treatment by decreasing, and ideally eliminating, positive tumor margins and iatrogenic damage to healthy tissue. Current state-of-the-art near-infrared fluorescence imaging systems are bulky and costly, lack sensitivity under surgical illumination, and lack co-registration accuracy between multimodal images. As a result, an overwhelming majority of physicians still rely on their unaided eyes and palpation as the primary sensing modalities for distinguishing cancerous from healthy tissue. Here we introduce an innovative design, comprising an artificial multispectral sensor inspired by the Morpho butterfly's compound eye, which can significantly improve image-guided surgery. By monolithically integrating spectral tapetal filters with photodetectors, we have realized a single-chip multispectral imager with 1000 x higher sensitivity and 7 x better spatial co-registration accuracy compared to clinical imaging systems in current use. Preclinical and clinical data demonstrate that this technology seamlessly integrates into the surgical workflow while providing surgeons with real-time information on the location of cancerous tissue and sentinel lymph nodes. Due to its low manufacturing cost, our bio-inspired sensor will provide resource-limited hospitals with much-needed technology to enable more accurate value-based health care. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreementen_US
dc.description.sponsorshipAir Force Office of Scientific Research (AFOSR) [FA9550-12-1-0321]; National Institutes of Health (NIH) [NCI R01 CA171651]; National Science Foundation (NSF) [1724615, 1740737]en_US
dc.language.isoenen_US
dc.publisherOPTICAL SOC AMERen_US
dc.relation.urlhttps://www.osapublishing.org/abstract.cfm?URI=optica-5-4-413en_US
dc.rights© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreementen_US
dc.titleBio-inspired imager improves sensitivity in near-infrared fluorescence image-guided surgeryen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Opt Scien_US
dc.identifier.journalOPTICAen_US
dc.description.noteOpen access journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleOptica
dc.source.volume5
dc.source.issue4
dc.source.beginpage413
refterms.dateFOA2018-05-24T17:43:22Z


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