Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
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Final Published version
Affiliation
Univ Arizona, Dept Mol & Cellular BiolUniv Arizona, Arizona Canc Ctr
Issue Date
2017-12
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TAYLOR & FRANCIS INCCitation
Kotaro Fujimaki & Guang Yao (2018) Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy, Molecular & Cellular Oncology, 5:1, e1403531, DOI: 10.1080/23723556.2017.1403531Journal
MOLECULAR & CELLULAR ONCOLOGYRights
© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The regulation cif cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.Note
Open access article.ISSN
2372-3556Version
Final published versionSponsors
NSF [DMS-1463137, DMS-1418172]; DARPA [WF911NF-14-1-0395]Additional Links
https://www.tandfonline.com/doi/full/10.1080/23723556.2017.1403531ae974a485f413a2113503eed53cd6c53
10.1080/23723556.2017.1403531