Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
AffiliationUniv Arizona, Dept Mol & Cellular Biol
Univ Arizona, Arizona Canc Ctr
MetadataShow full item record
PublisherTAYLOR & FRANCIS INC
CitationKotaro Fujimaki & Guang Yao (2018) Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy, Molecular & Cellular Oncology, 5:1, e1403531, DOI: 10.1080/23723556.2017.1403531
JournalMOLECULAR & CELLULAR ONCOLOGY
Rights© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC© Kotaro Fujimaki and Guang Yao
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractThe regulation cif cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment.
NoteOpen access article.
VersionFinal published version
SponsorsNSF [DMS-1463137, DMS-1418172]; DARPA [WF911NF-14-1-0395]