Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy
| dc.contributor.author | Fujimaki, Kotaro | |
| dc.contributor.author | Yao, Guang | |
| dc.date.accessioned | 2018-05-24T21:40:16Z | |
| dc.date.available | 2018-05-24T21:40:16Z | |
| dc.date.issued | 2017-12 | |
| dc.identifier.citation | Kotaro Fujimaki & Guang Yao (2018) Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy, Molecular & Cellular Oncology, 5:1, e1403531, DOI: 10.1080/23723556.2017.1403531 | en_US |
| dc.identifier.issn | 2372-3556 | |
| dc.identifier.doi | 10.1080/23723556.2017.1403531 | |
| dc.identifier.uri | http://hdl.handle.net/10150/627801 | |
| dc.description.abstract | The regulation cif cellular quiescence underlies numerous physiopathological phenomena. We recently found that quiescence depth can be tuned as to adjust a dimmer switch, by altering the expression of genes in the Retinoblastoma (Rb)-E2f pathway. Reducing quiescence depth may wake dormant cancer cells and make them susceptible to treatment. | en_US |
| dc.description.sponsorship | NSF [DMS-1463137, DMS-1418172]; DARPA [WF911NF-14-1-0395] | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | TAYLOR & FRANCIS INC | en_US |
| dc.relation.url | https://www.tandfonline.com/doi/full/10.1080/23723556.2017.1403531 | en_US |
| dc.rights | © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. | en_US |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | |
| dc.subject | cellular quiescence | en_US |
| dc.subject | quiescence depth | en_US |
| dc.subject | cell cycle entry | en_US |
| dc.subject | Rb-E2F pathway | en_US |
| dc.title | Crack the state of silence: Tune the depth of cellular quiescence for cancer therapy | en_US |
| dc.type | Article | en_US |
| dc.contributor.department | Univ Arizona, Dept Mol & Cellular Biol | en_US |
| dc.contributor.department | Univ Arizona, Arizona Canc Ctr | en_US |
| dc.identifier.journal | MOLECULAR & CELLULAR ONCOLOGY | en_US |
| dc.description.note | Open access article. | en_US |
| dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.source.journaltitle | Molecular & Cellular Oncology | |
| dc.source.volume | 5 | |
| dc.source.issue | 1 | |
| dc.source.beginpage | e1403531 | |
| refterms.dateFOA | 2018-05-24T21:40:16Z |
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