Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth
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Final Accepted Manuscript
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Univ Arizona, Dept Ecol & Evolutionary BiolIssue Date
2017-06
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NATURE PUBLISHING GROUPCitation
Wilson, B. A., Foy, S. G., Neme, R., & Masel, J. (2017). Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature ecology & evolution, 1(6), 0146.Journal
NATURE ECOLOGY & EVOLUTIONRights
© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
The phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, whereas the preadaptation hypothesis predicts that young genes will show extreme levels of rgb(204, 0, 0);">gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family and to the false positive annotation of protein-coding genes.Note
6 month embargo; published online: 24 April 2017ISSN
2397-334XPubMed ID
28642936Version
Final accepted manuscriptSponsors
John Templeton Foundation [39667]; National Institutes of Health [GM104040]; ERG grant NewGenes [322564]Additional Links
http://www.nature.com/articles/s41559-017-0146ae974a485f413a2113503eed53cd6c53
10.1038/s41559-017-0146
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