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    Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth

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    Author
    Wilson, Benjamin A.
    Foy, Scott G.
    Neme, Rafik cc
    Masel, Joanna
    Affiliation
    Univ Arizona, Dept Ecol & Evolutionary Biol
    Issue Date
    2017-06
    
    Metadata
    Show full item record
    Publisher
    NATURE PUBLISHING GROUP
    Citation
    Wilson, B. A., Foy, S. G., Neme, R., & Masel, J. (2017). Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature ecology & evolution, 1(6), 0146.
    Journal
    NATURE ECOLOGY & EVOLUTION
    Rights
    © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, whereas the preadaptation hypothesis predicts that young genes will show extreme levels of rgb(204, 0, 0);">gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family and to the false positive annotation of protein-coding genes.
    Note
    6 month embargo; published online: 24 April 2017
    ISSN
    2397-334X
    PubMed ID
    28642936
    DOI
    10.1038/s41559-017-0146
    Version
    Final accepted manuscript
    Sponsors
    John Templeton Foundation [39667]; National Institutes of Health [GM104040]; ERG grant NewGenes [322564]
    Additional Links
    http://www.nature.com/articles/s41559-017-0146
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41559-017-0146
    Scopus Count
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    UA Faculty Publications

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