Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationWilson, B. A., Foy, S. G., Neme, R., & Masel, J. (2017). Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature ecology & evolution, 1(6), 0146.
JournalNATURE ECOLOGY & EVOLUTION
Rights© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
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AbstractThe phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, whereas the preadaptation hypothesis predicts that young genes will show extreme levels of rgb(204, 0, 0);">gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family and to the false positive annotation of protein-coding genes.
Note6 month embargo; published online: 24 April 2017
VersionFinal accepted manuscript
SponsorsJohn Templeton Foundation ; National Institutes of Health [GM104040]; ERG grant NewGenes