Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth
AffiliationUniv Arizona, Dept Ecol & Evolutionary Biol
MetadataShow full item record
PublisherNATURE PUBLISHING GROUP
CitationWilson, B. A., Foy, S. G., Neme, R., & Masel, J. (2017). Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature ecology & evolution, 1(6), 0146.
JournalNATURE ECOLOGY & EVOLUTION
Rights© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractThe phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, whereas the preadaptation hypothesis predicts that young genes will show extreme levels of rgb(204, 0, 0);">gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family and to the false positive annotation of protein-coding genes.
Note6 month embargo; published online: 24 April 2017
VersionFinal accepted manuscript
SponsorsJohn Templeton Foundation ; National Institutes of Health [GM104040]; ERG grant NewGenes 
- From De Novo to "De Nono": The Majority of Novel Protein-Coding Genes Identified with Phylostratigraphy Are Old Genes or Recent Duplicates.
- Authors: Casola C
- Issue date: 2018 Nov 1
- A Continuum of Evolving De Novo Genes Drives Protein-Coding Novelty in Drosophila.
- Authors: Heames B, Schmitz J, Bornberg-Bauer E
- Issue date: 2020 May
- Readthrough Errors Purge Deleterious Cryptic Sequences, Facilitating the Birth of Coding Sequences.
- Authors: Kosinski LJ, Masel J
- Issue date: 2020 Jun 1
- Differences Between the Raw Material and the Products of <i>de Novo</i> Gene Birth Can Result from Mutational Biases.
- Authors: Nielly-Thibault L, Landry CR
- Issue date: 2019 Aug
- Gene Birth Contributes to Structural Disorder Encoded by Overlapping Genes.
- Authors: Willis S, Masel J
- Issue date: 2018 Sep