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dc.contributor.authorWilson, Benjamin A.
dc.contributor.authorFoy, Scott G.
dc.contributor.authorNeme, Rafik
dc.contributor.authorMasel, Joanna
dc.date.accessioned2018-05-29T20:35:11Z
dc.date.available2018-05-29T20:35:11Z
dc.date.issued2017-06
dc.identifier.citationWilson, B. A., Foy, S. G., Neme, R., & Masel, J. (2017). Young genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birth. Nature ecology & evolution, 1(6), 0146.en_US
dc.identifier.issn2397-334X
dc.identifier.pmid28642936
dc.identifier.doi10.1038/s41559-017-0146
dc.identifier.urihttp://hdl.handle.net/10150/627822
dc.description.abstractThe phenomenon of de novo gene birth from junk DNA is surprising, because random polypeptides are expected to be toxic. There are two conflicting views about how de novo gene birth is nevertheless possible: the continuum hypothesis invokes a gradual gene birth process, whereas the preadaptation hypothesis predicts that young genes will show extreme levels of rgb(204, 0, 0);">gene-like traits. We show that intrinsic structural disorder conforms to the predictions of the preadaptation hypothesis and falsifies the continuum hypothesis, with all genes having higher levels than translated junk DNA, but young genes having the highest level of all. Results are robust to homology detection bias, to the non-independence of multiple members of the same gene family and to the false positive annotation of protein-coding genes.en_US
dc.description.sponsorshipJohn Templeton Foundation [39667]; National Institutes of Health [GM104040]; ERG grant NewGenes [322564]en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.urlhttp://www.nature.com/articles/s41559-017-0146en_US
dc.rights© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.en_US
dc.titleYoung genes are highly disordered as predicted by the preadaptation hypothesis of de novo gene birthen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Ecol & Evolutionary Biolen_US
dc.identifier.journalNATURE ECOLOGY & EVOLUTIONen_US
dc.description.note6 month embargo; published online: 24 April 2017en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleNature Ecology & Evolution
dc.source.volume1
dc.source.issue6
dc.source.beginpage0146
refterms.dateFOA2017-10-24T00:00:00Z


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