Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation
Authorde la Tremblaye, Patricia B.
O’Neil, Darik A.
LaPorte, Megan J.
Cheng, Jeffrey P.
Beitchman, Joshua A.
Thomas, Theresa Currier
Bondi, Corina O.
Kline, Anthony E.
AffiliationUniv Arizona, Coll Med, Dept Child Hlth
KeywordsAntiepileptic drugs (AEDs)
Antipsychotic drugs (APDs)
Controlled cortical impact (CCI)
Fluid percussion (FP) injury
Morris water maze (MWM)
Traumatic brain injury (TBI)
MetadataShow full item record
PublisherPERGAMON-ELSEVIER SCIENCE LTD
CitationPatricia, B., O’Neil, D. A., LaPorte, M. J., Cheng, J. P., Beitchman, J. A., Thomas, T. C., ... & Kline, A. E. (2017). Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation. Neuroscience & Biobehavioral Reviews.
Rights© 2017 Elsevier Ltd. All rights reserved.
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AbstractThe aim of this review is to discuss the research presented in a symposium entitled "Current Progress in characterizing therapeutic strategies and challenges in experimental CNS injury" which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.
Note18 month embargo; published online: 30 May 2017
VersionFinal accepted manuscript
SponsorsNational Institutes of Health [HD069620, HD069620-S1, NS060005, NS084967, NS094950, NS099683]; University of Pittsburgh Physicians/UPMC Academic Foundation; Arizona Biomedical Research Commission through Arizona Department of Health Services [ADHS14-00003606]; Valley Research Partnership Awards [P2201607, P1201607]; Phoenix Children's Hospital Mission Support Funds