Show simple item record

dc.contributor.authorChang, Eugene H.*
dc.contributor.authorStern, Debra A.*
dc.contributor.authorWillis, Amanda L.*
dc.contributor.authorGuerra, Stefano*
dc.contributor.authorWright, Anne L.*
dc.contributor.authorMartinez, Fernando D.*
dc.date.accessioned2018-06-04T22:44:12Z
dc.date.available2018-06-04T22:44:12Z
dc.date.issued2018-04
dc.identifier.citationChang, E. H., Stern, D. A., Willis, A. L., Guerra, S., Wright, A. L., & Martinez, F. D. (2018). Early life risk factors for chronic sinusitis: A longitudinal birth cohort study. Journal of Allergy and Clinical Immunology, 141(4), 1291-1297.en_US
dc.identifier.issn00916749
dc.identifier.pmid29355680
dc.identifier.doi10.1016/j.jaci.2017.11.052
dc.identifier.urihttp://hdl.handle.net/10150/627878
dc.description.abstractBackground: Chronic sinusitis is a commonly diagnosed condition in adults who frequently present with late-stage disease and irreversible changes to the sinus mucosa. Understanding the natural history of chronic sinusitis is critical in developing therapies designed to prevent or slow the progression of disease. Objective: We sought to determine early life risk factors for adult sinusitis in a longitudinal cohort study (Tucson Children's Respiratory Study). Methods: Physician-diagnosed sinusitis was reported at age 6. Adult sinusitis between 22 and 32 years was defined as self-reported sinusitis plus physician-ordered sinus radiologic films. Atopy was assessed by skin prick test. Individuals were grouped into 4 phenotypes: no sinusitis (n = 621), transient childhood sinusitis only (n = 57), late-onset adult sinusitis only (n = 68), and early onset chronic sinusitis (childhood and adult sinusitis, n = 26). Results: Sinusitis was present in 10.8% of children and 12.2% of adults. Childhood sinusitis was the strongest independent risk factor for adult sinusitis (odds ratio = 4.2; 95% CI: 2.5-7.1; P < .0001; n = 772). Early onset chronic sinusitis was associated with increased serum IgE levels as early as at 9 months of age, atopy (assessed by skin prick test reactivity), childhood eczema and allergic rhinitis, frequent childhood colds, maternal asthma, and with increased prevalence of concurrent asthma. No association was found between late-onset adult sinusitis and any of the early life risk factors studied. Conclusions: We identified an early onset chronic sinusitis phenotype associated with a predisposition to viral infections/colds in early life, allergies, and asthma. Elucidation of the molecular mechanisms for this phenotype may lead to future therapies to prevent the progression of the disease into adult sinusitis.en_US
dc.description.sponsorshipNational Institutes of Health [NIH-R01 HL 132523]en_US
dc.language.isoenen_US
dc.publisherMOSBY-ELSEVIERen_US
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0091674918300800en_US
dc.rights© 2018 American Academy of Allergy, Asthma & Immunologyen_US
dc.subjectSinusitisen_US
dc.subjectasthmaen_US
dc.subjectallergyen_US
dc.subjectviralen_US
dc.subjectnatural historyen_US
dc.titleEarly life risk factors for chronic sinusitis: A longitudinal birth cohort studyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Otolaryngolen_US
dc.contributor.departmentUniv Arizona, Asthma & Airway Dis Res Ctren_US
dc.identifier.journalJOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGYen_US
dc.description.note12 month embargo; published online: 21 February 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of Allergy and Clinical Immunology
dc.source.volume141
dc.source.issue4
dc.source.beginpage1291
dc.source.endpage1297.e2


Files in this item

Thumbnail
Name:
TCRS_Sinusitis_R1clean.pdf
Size:
407.8Kb
Format:
PDF
Description:
Final Accepted Manuscript

This item appears in the following Collection(s)

Show simple item record