Solvent-free nitration of electron-rich arenes
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UA_deposited_Arene_Nitration_m ...
Embargo:
2018-10-03
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161.2Kb
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Final Accepted Manuscript
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TAYLOR & FRANCIS INCCitation
Bhumasamudram Jagadish, Nathaniel R. Hurley & Eugene A. Mash (2017) Solvent-free nitration of electron-rich arenes, Synthetic Communications, 47:24, 2395-2398, DOI: 10.1080/00397911.2017.1378682Journal
SYNTHETIC COMMUNICATIONSRights
© 2017 Taylor & FrancisCollection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Nitration of relatively electron-rich arenes does not require an additive or a solvent. For example, reaction on a gram scale of anisole with acetyl nitrate, generated in situ by mixing 100% HNO3 with acetic anhydride, produced 2,4-dinitroanisole in 82% yield after crystallization of the crude product. Results with five additional monosubstituted benzene derivatives possessing highly activated, weakly activated, or weakly deactivated rings are reported. [GRAPHICS] .Note
12 month embargo; published online: 03 October 2017ISSN
0039-79111532-2432