AffiliationUniv Arizona, Dept Psychol
Univ Arizona, Dept Neurology
Univ Arizona, BIO5
MetadataShow full item record
CitationSevag Kaladchibachi and Fabian Fernandez, “Precision Light for the Treatment of Psychiatric Disorders,” Neural Plasticity, vol. 2018, Article ID 5868570, 16 pages, 2018. https://doi.org/10.1155/2018/5868570.
RightsCopyright © 2018 Sevag Kaladchibachi and Fabian Fernandez. This is an open access article distributed under the Creative Commons Attribution License.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractCircadian timekeeping can be reset by brief flashes of light using stimulation protocols thousands of times shorter than those previously assumed to be necessary for traditional phototherapy. These observations point to a future where flexible architectures of nanosecond-, microsecond-, and millisecond-scale light pulses are compiled to reprogram the brain’s internal clock when it has been altered by psychiatric illness or advanced age. In the current review, we present a chronology of seminal experiments that established the synchronizing influence of light on the human circadian system and the efficacy of prolonged bright-light exposure for reducing symptoms associated with seasonal affective disorder. We conclude with a discussion of the different ways that precision flashes could be parlayed during sleep to effect neuroadaptive changes in brain function. This article is a contribution to a special issue on Circadian Rhythms in Regulation of Brain Processes and Role in Psychiatric Disorders curated by editors Shimon Amir, Karen Gamble, Oliver Stork, and Harry Pantazopoulos.
NoteOpen Access Article. UA Open Access Publishing Fund.
VersionFinal published version