Show simple item record

dc.contributor.authorVina, E.R.
dc.contributor.authorRan, D.
dc.contributor.authorAshbeck, E.L.
dc.contributor.authorKwoh, C.K.
dc.date.accessioned2018-06-11T19:04:11Z
dc.date.available2018-06-11T19:04:11Z
dc.date.issued2018-04
dc.identifier.citationE.R. Vina, D. Ran, E.L. Ashbeck, C.K. Kwoh, Natural history of pain and disability among African–Americans and Whites with or at risk for knee osteoarthritis: A longitudinal study, Osteoarthritis and Cartilage, 26(4), pp 471-479, https://doi.org/10.1016/j.joca.2018.01.020.en_US
dc.identifier.issn10634584
dc.identifier.pmid29408279
dc.identifier.doi10.1016/j.joca.2018.01.020
dc.identifier.urihttp://hdl.handle.net/10150/627923
dc.description.abstractObjective: Compare knee pain and disability between African Americans (AAs) and Whites (WHs), with or at risk of knee osteoarthritis (KOA), over 9 years, and evaluate racial disparities in KOA-related symptoms across socioeconomic and clinical characteristics. Design: Osteoarthritis Initiative (OAI) participants were evaluated annually over 9 years for pain and disability, assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and a numerical rating scale (NRS) for knee pain severity. Mean annual WOMAC pain, NRS pain, and WOMAC disability levels were estimated by race using mixed effects models, adjusted for age, sex, education, marital status, body mass index (BMI), depression, and baseline Kellgrene-Lawrence grade score. Race-specific mean WOMAC pain scores were also estimated in analyses stratified by socioeconomic and clinical characteristics. Results: AAs reported worse mean WOMAC pain compared to WHs at baseline (3.69 vs 2.20; P <= 0.0001) and over 9 years of follow-up, with similar disparities reflected in NRS pain severity and WOMAC disability. Radiographic severity did not account for the differences in pain and disability, as substantial and significant racial disparities were observed after stratification by Kellgrene-Lawrence grade. Depression and low income exacerbated differences in WOMAC pain between AAs and WHs by a substantial and significant magnitude. Conclusions: Over 9 years of follow-up, AAs reported persistently greater KOA symptoms than WHs. Socioeconomically and clinically disadvantaged AAs reported the most pronounced disparities in pain and disability. (C) 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipNIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) [K23AR067226, R01AR066601]en_US
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S1063458418300797en_US
dc.rights© 2018 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.en_US
dc.subjectOsteoarthritisen_US
dc.subjectKnee osteoarthritisen_US
dc.subjectRaceen_US
dc.subjectOutcome measuresen_US
dc.subjectPainen_US
dc.subjectLongitudinalen_US
dc.titleNatural history of pain and disability among African–Americans and Whites with or at risk for knee osteoarthritis: A longitudinal studyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Med, Div Rheumatolen_US
dc.contributor.departmentUniv Arizona, Arizona Arthrit Ctren_US
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostaten_US
dc.identifier.journalOSTEOARTHRITIS AND CARTILAGEen_US
dc.description.note12 month embargo; published online: 2 February 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleOsteoarthritis and Cartilage
dc.source.volume26
dc.source.issue4
dc.source.beginpage471
dc.source.endpage479


Files in this item

Thumbnail
Name:
Race_OA_Pain_Progression_01171 ...
Size:
868.7Kb
Format:
PDF
Description:
Final Accepted Manuscript

This item appears in the following Collection(s)

Show simple item record