AffiliationUniv Arizona, Coll Med
MetadataShow full item record
PublisherELSEVIER SCI LTD
CitationP. Angelos, D.M. Hartl, J.P. Shah, I.J. Nixon, R.P. Owen, A. Rinaldo, J.P. Rodrigo, A.R. Shaha, C.E. Silver, C. Suárez, A. Ferlito, Ethical issues in non-intervention trials for thyroid cancer, European Journal of Surgical Oncology, 44 (3), pp 316-320, https://doi.org/10.1016/j.ejso.2017.03.002
Rights© 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractIn recent years, the increasing numbers of small, apparently indolent thyroid cancers diagnosed in the world have encouraged investigators to consider non-intervention as an alternative to surgical management. In the following pages, the prospect of a non-intervention trial for thyroid cancer is considered with attention to the ethical issues that such a trial might raise. Such a non-intervention trial is analyzed relative to 7 ethical considerations: the social or scientific value of the research, the scientific validity of the trial, the necessity of fair selection of participants, a favorable risk-benefit ratio for trial participants, independent review of the trial, informed consent, and allowing the study participants to withdraw from the trial. A non-intervention trial for thyroid cancer is also considered relative to the central concept of equipoise. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Note12 month embargo; published online: 16 March 2017
VersionFinal accepted manuscript
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- Issue date: 2003 Feb
- Ethical issues of participant recruitment in surgical clinical trials.
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- Issue date: 2013 Oct
- [Ethical controversies on the use of placebo as control treatment in clinical trials in neurology].
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- Issue date: 2007 Mar
- Statistical power, the Belmont report, and the ethics of clinical trials.
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