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dc.contributor.advisorLopez, Gerardo
dc.contributor.advisorLybarger, Lonnie
dc.contributor.authorDiaz, David Andrew
dc.creatorDiaz, David Andrew
dc.date.accessioned2018-06-25T21:02:03Z
dc.date.available2018-06-25T21:02:03Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/628080
dc.description.abstractThere is increasing evidence of a deep integration between microbes and human physiological function. With such extensive communication in both directions, it is arguable that a major disruption on either side would have substantial impact on the other. A number of modern diseases have been associated with shifts in the microbiome populations such as inflammatory bowel disease, diabetes, acne vulgaris, etc. However, which initiates the other often remains unclear. From the standpoint of dysbiosis preceding the pathologies, it presents a route by which environmental exposures can indirectly impact human physiology. This idea pertains in particular to compounds like the herbicide glyphosate which is alleged to be non- toxic to human cells. Because this compound has been demonstrated to impact bacteria, it presents a whole other layer of consideration in regards to its potential to cause disease in humans. While studies have been done to assess impact of this compound on different microbial communities with mixed results, none seem to have examined impact on human microflora specifically. This thesis examines the association between the dysbiosis and human disease from the angle of disease occurring as an effect of the dysbiosis. Ultimately, the hypothesis is that glyphosate exposure is sufficient to induce many modern diseases via disruption of the microbiome as illustrated in Figure 1. Furthermore, included here are proposed future experiments to explore glyphosate’s potential to perturb the microbiome..en_US
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectDysbiosisen_US
dc.subjectGlyphosateen_US
dc.subjectInflammationen_US
dc.subjectMetabolismen_US
dc.subjectMicrobiomeen_US
dc.titleGlyphosate Holds Potential to Induce Dysbiosis Associated Pathologies in Humansen_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.levelmastersen_US
dc.contributor.committeememberLantz, Clark
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineCellular and Molecular Medicineen_US
thesis.degree.nameM.S.en_US
refterms.dateFOA2018-06-25T21:02:04Z


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