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dc.contributor.advisorDarnell, Diana
dc.contributor.advisorGoldman, Steven
dc.contributor.authorRamos, Paulina Joanna
dc.creatorRamos, Paulina Joanna
dc.date.accessioned2018-06-27T17:33:54Z
dc.date.available2018-06-27T17:33:54Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10150/628157
dc.description.abstractInsulin-like growth factor 1 (IGF-1) signaling plays a role in the regulation of heart disease. While most therapeutics target the consequences of cell loss and tissue necrosis, the underlying pathophysiology is not addressed. Emerging therapeutics are exploring the potential effects of IGF-1 in cardiac repair and regeneration. IGF-1 has established a role as a cardioprotective cytokine with pleiotropic effects regulating cell growth, proliferation, metabolism, and survival in the heart. Local expression of IGF-1 in cardiac cells constitutes protection from irreversible loss of cell function post cardiac injury. Its deficiency is implicated in dysregulation of IGF-1 signaling and associated with reductions in heart function. Methods to directly increase endogenous levels of IGF-1 in the injured heart are emerging and while the optimal delivery methods, doses, time spans, and frequencies may not be established, it is known that IGF-1 is a necessary component in sustaining cardiomyocyte function in the diseased and failing heart. In this review, I provide background on heart failure and the pathophysiological injurious processes that up and coming therapeutics, targeting IGF-1, can potentially modulate, with IGF-1 as a regulator of cardiac repair and regeneration.en_US
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectHeart Failureen_US
dc.subjectIGF-1en_US
dc.titleIGF-1 as a Target in Emerging Heart Failure Therapeuticsen_US
dc.typetexten_US
dc.typeElectronic Thesisen_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.levelmastersen_US
dc.contributor.committeememberLancaster, Jordan
dc.contributor.committeememberAdamas-Rappaport, William
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineCellular and Molecular Medicineen_US
thesis.degree.nameM.S.en_US
refterms.dateFOA2018-06-27T17:33:55Z


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