AuthorJeong, Kyoung Sook
Griffin, Stephanie C.
Jacobs, Elizabeth T.
Littau, Sally R.
Peate, Wayne F.
Richt, Crystal M.
Burgess, Jefferey L.
AffiliationUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Commun Environm & Policy
Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat
Univ Arizona, Genet Core, Arizona Res Labs
MetadataShow full item record
PublisherLIPPINCOTT WILLIAMS & WILKINS
CitationJeong, K. S., Zhou, J., Griffin, S. C., Jacobs, E. T., Dearmon-Moore, D., Zhai, J., … Burgess, J. L. (2018). MicroRNA Changes in Firefighters. Journal of Occupational and Environmental Medicine, 60(5), 469–474. http://doi.org/10.1097/JOM.0000000000001307
RightsCopyright © 2018 by the American College of Occupational and Environmental Medicine
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractObjectives: Firefighters have elevated cancer incidence and mortality rates. MicroRNAs play prominent roles in carcinogenesis, but have not been previously evaluated in irefighters. Methods: Blood from 52 incumbent and 45 new recruit nonsmoking firefighters was analyzed for microRNA expression, and the results adjusted for age, obesity, ethnicity, and multiple comparisons. Results: Nine microRNAs were identified with at least a 1.5-fold significant difference between groups. All six microRNAs with decreased expression in incumbent firefighters have been reported to have tumor suppressor activity or are associated with cancer survival, and two of the three microRNAs with increased expression in incumbent firefighters have activities consistent with cancer promotion, with the remaining microRNA associated with neurological disease. Conclusion: Incumbent firefighters showed differential microRNA expression compared with new recruits, providing potential mechanisms for increased cancer risk in firefighters.
NoteOpen access article.
VersionFinal published version
SponsorsUS Federal Emergency Management Agency Assistance to Firefighters Grant program [EMW-2014-FP-00200]