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dc.contributor.authorMorrison, Erin S.
dc.contributor.authorBadyaev, Alexander V.
dc.date.accessioned2018-07-16T17:44:09Z
dc.date.available2018-07-16T17:44:09Z
dc.date.issued2018-05
dc.identifier.citationMorrison, E. S. and Badyaev, A. V. (2018), Structure versus time in the evolutionary diversification of avian carotenoid metabolic networks. J. Evol. Biol., 31: 764-772. doi:10.1111/jeb.13257en_US
dc.identifier.issn1010061X
dc.identifier.pmid29485222
dc.identifier.doi10.1111/jeb.13257
dc.identifier.urihttp://hdl.handle.net/10150/628228
dc.description.abstractHistorical associations of genes and proteins are thought to delineate pathways available to subsequent evolution; however, the effects of past functional involvements on contemporary evolution are rarely quantified. Here, we examined the extent to which the structure of a carotenoid enzymatic network persists in avian evolution. Specifically, we tested whether the evolution of carotenoid networks was most concordant with phylogenetically structured expansion from core reactions of common ancestors or with subsampling of biochemical pathway modules from an ancestral network. We compared structural and historical associations in 467 carotenoid networks of extant and ancestral species and uncovered the overwhelming effect of pre-existing metabolic network structure on carotenoid diversification over the last 50 million years of avian evolution. Over evolutionary time, birds repeatedly subsampled and recombined conserved biochemical modules, which likely maintained the overall structure of the carotenoid metabolic network during avian evolution. These findings explain the recurrent convergence of evolutionary distant species in carotenoid metabolism and weak phylogenetic signal in avian carotenoid evolution. Remarkable retention of an ancient metabolic structure throughout extensive and prolonged ecological diversification in avian carotenoid metabolism illustrates a fundamental requirement of organismal evolution - historical continuity of a deterministic network that links past and present functional associations of its components.en_US
dc.description.sponsorshipNational Science Foundation [DEB-0077804, IBN-0218313]; David and Lucille Packard Foundation; Amherst College Graduate Fellowships; University of Arizona Galileo Circle Scholarshipen_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.urlhttp://doi.wiley.com/10.1111/jeb.2018.31.issue-5en_US
dc.relation.urlhttp://doi.wiley.com/10.1111/jeb.13257en_US
dc.rights© 2018 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2018 European Society For Evolutionary Biologyen_US
dc.subjectfunctional moduleen_US
dc.subjectmetabolic network evolutionen_US
dc.subjectmodularityen_US
dc.subjectnetwork structureen_US
dc.titleStructure versus time in the evolutionary diversification of avian carotenoid metabolic networksen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Ecol & Evolutionary Biolen_US
dc.identifier.journalJOURNAL OF EVOLUTIONARY BIOLOGYen_US
dc.description.note12 month embargo; published online: 27 February 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleJournal of Evolutionary Biology
dc.source.volume31
dc.source.issue5
dc.source.beginpage764
dc.source.endpage772


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