Show simple item record

dc.contributor.authorFeatherston, Jonathan
dc.contributor.authorArakaki, Yoko
dc.contributor.authorHanschen, Erik R
dc.contributor.authorFerris, Patrick J
dc.contributor.authorMichod, Richard E
dc.contributor.authorOlson, Bradley J S C
dc.contributor.authorNozaki, Hisayoshi
dc.contributor.authorDurand, Pierre M
dc.date.accessioned2018-07-18T19:01:48Z
dc.date.available2018-07-18T19:01:48Z
dc.date.issued2018-04
dc.identifier.citationJonathan Featherston, Yoko Arakaki, Erik R Hanschen, Patrick J Ferris, Richard E Michod, Bradley J S C Olson, Hisayoshi Nozaki, Pierre M Durand; The 4-Celled Tetrabaena socialis Nuclear Genome Reveals the Essential Components for Genetic Control of Cell Number at the Origin of Multicellularity in the Volvocine Lineage, Molecular Biology and Evolution, Volume 35, Issue 4, 1 April 2018, Pages 855–870, https://doi.org/10.1093/molbev/msx332en_US
dc.identifier.issn0737-4038
dc.identifier.issn1537-1719
dc.identifier.pmid29294063
dc.identifier.doi10.1093/molbev/msx332
dc.identifier.urihttp://hdl.handle.net/10150/628254
dc.description.abstractMulticellularity is the premier example of a major evolutionary transition in individuality and was a foundational event in the evolution of macroscopic biodiversity. The volvocine chlorophyte lineage is well suited for studying this process. Extant members span unicellular, simple colonial, and obligate multicellular taxa with germ-soma differentiation. Here, we report the nuclear genome sequence of one of the most morphologically simple organisms in this lineage-the 4-celled colonial Tetrabaena socialis and compare this to the three other complete volvocine nuclear genomes. Using conservative estimates of gene family expansions a minimal set of expanded gene families was identified that associate with the origin of multicellularity. These families are rich in genes related to developmental processes. A subset of these families is lineage specific, which suggests that at a genomic level the evolution of multicellularity also includes lineagespecific molecular developments. Multiple points of evidence associate modifications to the ubiquitin proteasomal pathway (UPP) with the beginning of coloniality. Genes undergoing positive or accelerating selection in the multicellular volvocines were found to be enriched in components of the UPP and gene families gained at the origin of multicellularity include components of the UPP. A defining feature of colonial/multicellular life cycles is the genetic control of cell number. The genomic data presented here, which includes diversification of cell cycle genes and modifications to the UPP, align the genetic components with the evolution of this trait.en_US
dc.description.sponsorshipNational Aeronautics and Space Administration [NNX13AH41G]; National Science Foundation [MCB-1412395]; University of Witwatersrand Department of Science and Technology National Research Foundation Centre of Excellence in Palaeosciences; University of Witwatersrand, Faculty of Health Science granten_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.urlhttps://academic.oup.com/mbe/article/35/4/855/4774723en_US
dc.rights© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.en_US
dc.subjectVolvocinesen_US
dc.subjectmulticellularityen_US
dc.subjectTetrabaena socialisen_US
dc.subjectevolutionary genomicsen_US
dc.titleThe 4-Celled Tetrabaena socialis Nuclear Genome Reveals the Essential Components for Genetic Control of Cell Number at the Origin of Multicellularity in the Volvocine Lineageen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Dept Ecol & Evolutionary Biolen_US
dc.identifier.journalMOLECULAR BIOLOGY AND EVOLUTIONen_US
dc.description.note12 month embargo; published online: 26 December 2017en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleMolecular Biology and Evolution
dc.source.volume35
dc.source.issue4
dc.source.beginpage855
dc.source.endpage870


Files in this item

Thumbnail
Name:
MBEsubmissionPDF.pdf
Size:
10.25Mb
Format:
PDF
Description:
Final Accepted Manuscript

This item appears in the following Collection(s)

Show simple item record