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dc.contributor.authorProaño, Alvaro
dc.contributor.authorBui, David P
dc.contributor.authorLópez, José W
dc.contributor.authorVu, Nancy M
dc.contributor.authorBravard, Marjory A
dc.contributor.authorLee, Gwenyth O
dc.contributor.authorTracey, Brian H
dc.contributor.authorXu, Ziyue
dc.contributor.authorComina, Germán
dc.contributor.authorTicona, Eduardo
dc.contributor.authorMollura, Daniel J
dc.contributor.authorFriedland, Jon S
dc.contributor.authorMoore, David A J
dc.contributor.authorEvans, Carlton A
dc.contributor.authorCaligiuri, Philip
dc.contributor.authorGilman, Robert H
dc.date.accessioned2018-07-23T18:15:01Z
dc.date.available2018-07-23T18:15:01Z
dc.date.issued2018-06-01
dc.identifier.citationProaño, A., Bui, D. P., López, J. W., Vu, N. M., Bravard, M. A., Lee, G. O., ... & Mollura, D. J. (2018). Cough Frequency During Treatment Associated With Baseline Cavitary Volume and Proximity to the Airway in Pulmonary TB. Chest, 153(6), 1358-1367.en_US
dc.identifier.issn1931-3543
dc.identifier.pmid29559307
dc.identifier.doi10.1016/j.chest.2018.03.006
dc.identifier.urihttp://hdl.handle.net/10150/628266
dc.description.abstractCough frequency, and its duration, is a biomarker that can be used in low-resource settings without the need of laboratory culture and has been associated with transmission and treatment response. Radiologic characteristics associated with increased cough frequency may be important in understanding transmission. The relationship between cough frequency and cavitary lung disease has not been studied. We analyzed data in 41 adults who were HIV negative and had culture-confirmed, drug-susceptible pulmonary TB throughout treatment. Cough recordings were based on the Cayetano Cough Monitor, and sputum samples were evaluated using microscopic observation drug susceptibility broth culture; among culture-positive samples, bacillary burden was assessed by means of time to positivity. CT scans were analyzed by a US-board-certified radiologist and a computer-automated algorithm. The algorithm evaluated cavity volume and cavitary proximity to the airway. CT scans were obtained within 1 month of treatment initiation. We compared small cavities (≤ 7 mL) and large cavities (> 7 mL) and cavities located closer to (≤ 10 mm) and farther from (> 10 mm) the airway to cough frequency and cough cessation until treatment day 60. Cough frequency during treatment was twofold higher in participants with large cavity volumes (rate ratio [RR], 1.98; P = .01) and cavities located closer to the airway (RR, 2.44; P = .001). Comparably, cough ceased three times faster in participants with smaller cavities (adjusted hazard ratio [HR], 2.89; P = .06) and those farther from the airway (adjusted HR, 3.61;, P = .02). Similar results were found for bacillary burden and culture conversion during treatment. Cough frequency during treatment is greater and lasts longer in patients with larger cavities, especially those closer to the airway.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases [R21AI094143]; Fogarty International Center at the National Institutes of Health [D43TW006581, D43TW001140, D43TW010074, R25TW009340, R24TW007988, D43TW009349]; Grand Challenges Canada [0539-01-10, 0537-01-10]; Center for Infectious Disease Imaging; National Institute of Allergy and Infectious Diseases; National Institute of Biomedical Imaging and Bioengineering from the National Institutes of Health; Wellcome Trust [078067/Z/05/Z, 105788/Z/14/Z, 201251/Z/16/Z]; Imperial Biomedical Research Centre; Joint Global Health Trials [MR/K007467/1]; government of Canada [W5_PER_CDT1_PRISMA]; Bill & Melinda Gates Foundation [OPP1118545]; Innovation for Health and Development fundingen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.rightsCopyright 2018 The Authors. Published by Elsevier Inc under license from the American College of Chest Physicians. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectCTen_US
dc.subjectcoughen_US
dc.subjectmycobacteriaen_US
dc.subjecttuberculosisen_US
dc.titleCough Frequency During Treatment Associated With Baseline Cavitary Volume and Proximity to the Airway in Pulmonary TB.en_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat, Tucson, AZ USAen_US
dc.identifier.journalCHESTen_US
dc.description.noteOpen access articleen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitleChest
refterms.dateFOA2018-07-23T18:15:02Z


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