Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment
AuthorHockenberry, Marilyn J.
Moore, Ida M. (Ki)
Scheurer, Michael E.
Hooke, Mary C.
Taylor, Olga A.
Koerner, Kari M.
Gundy, Patricia M.
AffiliationUniv Arizona, Coll Nursing, Biobehav Hlth Sci Div
MetadataShow full item record
PublisherSAGE PUBLICATIONS INC
CitationHockenberry, M. J., Moore, I. M., Scheurer, M. E., Hooke, M. C., Taylor, O. A., Koerner, K. M., ... & Pan, W. (2018). Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological research for nursing, 20(4), 403-409. https://doi.org/10.1177/1099800418772907
JournalBIOLOGICAL RESEARCH FOR NURSING
RightsCopyright © 2018, © SAGE Publications
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractThe focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise in therapy can negatively influence the quality of life and, even more notably, jeopardize chances for long-term survival. This study examined biologic mechanisms that influence fatigue caused by increased reactive oxidative species (ROS) or actual failure of the antioxidant defense system due to genetic variation by investigating reactive nitrosative species, a downstream consequence of ROS. The specific aims of this study were to characterize the trajectory of nitrosative stress during acute lymphoblastic leukemia treatment and evaluate the influence of nitrosative stress on fatigue. A repeated measures design was used to evaluate the fatigue experienced by 186 children and adolescents, 3-18 years of age, with a diagnosis of leukemia during the most intense phase of treatment. An established biomarker of nitrosative stress, protein 3-nitrotyrosine (3NT) residues in the cerebral spinal fluid, was evaluated at diagnosis, postinduction, and consolidation phases of treatment. Higher fatigue was associated with higher 3NT levels at the beginning of treatment. Two distinct groups of children experienced either consistently high or consistently low 3NT levels across the treatment trajectory, from diagnosis to 12 months postinduction. Findings from this study support continued exploration into the phenotypic biochemical mechanisms that influence a reactive response to childhood cancer treatment.
VersionFinal accepted manuscript
- Fatigue and Oxidative Stress in Children Undergoing Leukemia Treatment.
- Authors: Rodgers C, Sanborn C, Taylor O, Gundy P, Pasvogel A, Moore IM, Hockenberry MJ
- Issue date: 2016 Oct
- Influence of Inflammatory and Oxidative Stress Pathways on Longitudinal Symptom Experiences in Children With Leukemia.
- Authors: Hockenberry MJ, Pan W, Scheurer ME, Hooke MC, Taylor O, Koerner K, Montgomery D, Whitman S, Mitby P, Moore I
- Issue date: 2019 Oct
- The influence of oxidative stress on symptom occurrence, severity, and distress during childhood leukemia treatment.
- Authors: Hockenberry MJ, Taylor OA, Pasvogel A, Rodgers C, McCarthy K, Gundy P, Montgomery DW, Ribbeck P, Scheurer ME, Moore IM
- Issue date: 2014 Jul 1
- F2-isoprostanes: a measure of oxidative stress in children receiving treatment for leukemia.
- Authors: Hockenberry MJ, Taylor OA, Gundy PM, Ross AK, Pasvogel A, Montgomery D, Ribbeck P, McCarthy K, Moore I
- Issue date: 2014 Jul
- Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia.
- Authors: Cheung YT, Brinkman TM, Mulrooney DA, Mzayek Y, Liu W, Banerjee P, Panoskaltsis-Mortari A, Srivastava D, Pui CH, Robison LL, Hudson MM, Krull KR
- Issue date: 2017 Sep 1