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    Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment

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    Author
    Hockenberry, Marilyn J.
    Moore, Ida M. (Ki)
    Scheurer, Michael E.
    Hooke, Mary C.
    Taylor, Olga A.
    Koerner, Kari M.
    Gundy, Patricia M.
    Pan, Wei
    Affiliation
    Univ Arizona, Coll Nursing, Biobehav Hlth Sci Div
    Issue Date
    2018-07
    Keywords
    nitrosative stress
    fatigue
    leukemia
    
    Metadata
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    Publisher
    SAGE PUBLICATIONS INC
    Citation
    Hockenberry, M. J., Moore, I. M., Scheurer, M. E., Hooke, M. C., Taylor, O. A., Koerner, K. M., ... & Pan, W. (2018). Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological research for nursing, 20(4), 403-409. https://doi.org/10.1177/1099800418772907
    Journal
    BIOLOGICAL RESEARCH FOR NURSING
    Rights
    Copyright © 2018, © SAGE Publications
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    The focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise in therapy can negatively influence the quality of life and, even more notably, jeopardize chances for long-term survival. This study examined biologic mechanisms that influence fatigue caused by increased reactive oxidative species (ROS) or actual failure of the antioxidant defense system due to genetic variation by investigating reactive nitrosative species, a downstream consequence of ROS. The specific aims of this study were to characterize the trajectory of nitrosative stress during acute lymphoblastic leukemia treatment and evaluate the influence of nitrosative stress on fatigue. A repeated measures design was used to evaluate the fatigue experienced by 186 children and adolescents, 3-18 years of age, with a diagnosis of leukemia during the most intense phase of treatment. An established biomarker of nitrosative stress, protein 3-nitrotyrosine (3NT) residues in the cerebral spinal fluid, was evaluated at diagnosis, postinduction, and consolidation phases of treatment. Higher fatigue was associated with higher 3NT levels at the beginning of treatment. Two distinct groups of children experienced either consistently high or consistently low 3NT levels across the treatment trajectory, from diagnosis to 12 months postinduction. Findings from this study support continued exploration into the phenotypic biochemical mechanisms that influence a reactive response to childhood cancer treatment.
    ISSN
    1099-8004
    1552-4175
    PubMed ID
    29716390
    DOI
    10.1177/1099800418772907
    Version
    Final accepted manuscript
    Additional Links
    http://journals.sagepub.com/doi/10.1177/1099800418772907
    ae974a485f413a2113503eed53cd6c53
    10.1177/1099800418772907
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