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dc.contributor.authorHockenberry, Marilyn J.
dc.contributor.authorMoore, Ida M. (Ki)
dc.contributor.authorScheurer, Michael E.
dc.contributor.authorHooke, Mary C.
dc.contributor.authorTaylor, Olga A.
dc.contributor.authorKoerner, Kari M.
dc.contributor.authorGundy, Patricia M.
dc.contributor.authorPan, Wei
dc.date.accessioned2018-07-24T17:33:40Z
dc.date.available2018-07-24T17:33:40Z
dc.date.issued2018-07
dc.identifier.citationHockenberry, M. J., Moore, I. M., Scheurer, M. E., Hooke, M. C., Taylor, O. A., Koerner, K. M., ... & Pan, W. (2018). Influence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatment. Biological research for nursing, 20(4), 403-409. https://doi.org/10.1177/1099800418772907en_US
dc.identifier.issn1099-8004
dc.identifier.issn1552-4175
dc.identifier.pmid29716390
dc.identifier.doi10.1177/1099800418772907
dc.identifier.urihttp://hdl.handle.net/10150/628284
dc.description.abstractThe focus on a cure for childhood leukemia over the last three decades has resulted in survival rates of more than 80%. However, efforts to manage leukemia-treatment symptoms have not kept pace with new therapies. Symptom toxicity during treatment can result in complications, treatment delays, and therapy dose reductions. Compromise in therapy can negatively influence the quality of life and, even more notably, jeopardize chances for long-term survival. This study examined biologic mechanisms that influence fatigue caused by increased reactive oxidative species (ROS) or actual failure of the antioxidant defense system due to genetic variation by investigating reactive nitrosative species, a downstream consequence of ROS. The specific aims of this study were to characterize the trajectory of nitrosative stress during acute lymphoblastic leukemia treatment and evaluate the influence of nitrosative stress on fatigue. A repeated measures design was used to evaluate the fatigue experienced by 186 children and adolescents, 3-18 years of age, with a diagnosis of leukemia during the most intense phase of treatment. An established biomarker of nitrosative stress, protein 3-nitrotyrosine (3NT) residues in the cerebral spinal fluid, was evaluated at diagnosis, postinduction, and consolidation phases of treatment. Higher fatigue was associated with higher 3NT levels at the beginning of treatment. Two distinct groups of children experienced either consistently high or consistently low 3NT levels across the treatment trajectory, from diagnosis to 12 months postinduction. Findings from this study support continued exploration into the phenotypic biochemical mechanisms that influence a reactive response to childhood cancer treatment.en_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.urlhttp://journals.sagepub.com/doi/10.1177/1099800418772907en_US
dc.rightsCopyright © 2018, © SAGE Publicationsen_US
dc.subjectnitrosative stressen_US
dc.subjectfatigueen_US
dc.subjectleukemiaen_US
dc.titleInfluence of Nitrosative Stress on Fatigue During Childhood Leukemia Treatmenten_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Nursing, Biobehav Hlth Sci Diven_US
dc.identifier.journalBIOLOGICAL RESEARCH FOR NURSINGen_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleBiological Research For Nursing
dc.source.volume20
dc.source.issue4
dc.source.beginpage403
dc.source.endpage409
refterms.dateFOA2018-07-24T17:33:40Z


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