Synergistic interaction of the cannabinoid and death receptor systems - a potential target for future cancer therapies?
AffiliationUniv Arizona, Coll Med, Dept Pharmacol
TNF-related apoptosis-inducing ligand
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CitationKeresztes, A. and Streicher, J. M. (2017), Synergistic interaction of the cannabinoid and death receptor systems – a potential target for future cancer therapies?. FEBS Lett, 591: 3235-3251. doi:10.1002/1873-3468.12863
Rights© 2017 Federation of European Biochemical Societies
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AbstractCannabinoid receptors have been shown to interact with other receptors, including tumor necrosis factor receptor superfamily (TNFRS) members, to induce cancer cell death. When cannabinoids and death‐inducing ligands (including TNF‐related apoptosis‐inducing ligand) are administered together, they have been shown to synergize and demonstrate enhanced antitumor activity in vitro. Certain cannabinoid ligands have been shown to sensitize cancer cells and synergistically interact with members of the TNFRS, thus suggesting that the combination of cannabinoids with death receptor (DR) ligands induces additive or synergistic tumor cell death. This review summarizes recent findings on the interaction of the cannabinoid and DR systems and suggests possible clinical co‐application of cannabinoids and DR ligands in the treatment of various malignancies.
Note12 month embargo; published online: 26 September 2017
VersionFinal accepted manuscript