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dc.contributor.authorDeshpande, Neha R.
dc.contributor.authorUhrlaub, Jennifer L.
dc.contributor.authorWay, Sing Sing
dc.contributor.authorNikolich-Žugich, Janko
dc.contributor.authorKuhns, Michael S.
dc.date.accessioned2018-08-09T18:00:07Z
dc.date.available2018-08-09T18:00:07Z
dc.date.issued2018-06-04
dc.identifier.citationDeshpande NR, Uhrlaub JL, Way SS, Nikolich-Žugich J, Kuhns MS (2018) A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice. PLoS ONE 13(6): e0198354. https://doi.org/10.1371/journal.pone.0198354en_US
dc.identifier.issn1932-6203
dc.identifier.pmid29864157
dc.identifier.doi10.1371/journal.pone.0198354
dc.identifier.urihttp://hdl.handle.net/10150/628376
dc.description.abstractT cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naive CD4(+) and CD8(+) T cells declines. However, unlike for CD8(+) T cells, there are more naive and memory phenotype CD4(+) T cells that bind foreign pMHCII in old mice (18-22 months) than adults (12-15 weeks), suggesting increased promiscuity of pMHCII recognition with aging. Here we asked if CD4(+) T cell responses to immunization or infection increase with aging since the magnitude of a CD4(+) T cell response to a foreign pMHCII is proportional to the size of the precursor population in adult mice. We observed no difference in the number of pMHCII-specific CD4(+) T cells in adult versus old mice for pooled secondary lymphoid organs after immunization, bacterial infection, or viral infection, but we did observe diminished numbers of pMHCII-specific CD4(+) T cells in both the draining lymph node and brain of old mice after West Nile virus infection. These data indicate that an increased precursor frequency does not translate into more robust responses upon immunization or infection in old mice.en_US
dc.description.sponsorshipNIH/NIAID [HHSN272201100017C]; Pew Charitable Trusts; UACC/ALR Cytometry Core Facility; Cancer Center Support Grant [CCSG-CA 023074]en_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0198354en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0198354.g001en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0198354.g002en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0198354.g003en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0198354.g004en_US
dc.rights© 2018 Deshpande et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licenseen_US
dc.titleA disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged miceen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Med, Dept Immunobiolen_US
dc.contributor.departmentUniv Arizona, Coll Med, BIO Inst 5en_US
dc.contributor.departmentUniv Arizona, Coll Med, Arizona Ctr Agingen_US
dc.identifier.journalPLOS ONEen_US
dc.description.noteOpen access journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitlePLOS ONE
dc.source.volume13
dc.source.issue6
dc.source.beginpagee0198354
refterms.dateFOA2018-08-09T18:00:08Z


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