A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice
dc.contributor.author | Deshpande, Neha R. | |
dc.contributor.author | Uhrlaub, Jennifer L. | |
dc.contributor.author | Way, Sing Sing | |
dc.contributor.author | Nikolich-Žugich, Janko | |
dc.contributor.author | Kuhns, Michael S. | |
dc.date.accessioned | 2018-08-09T18:00:07Z | |
dc.date.available | 2018-08-09T18:00:07Z | |
dc.date.issued | 2018-06-04 | |
dc.identifier.citation | Deshpande NR, Uhrlaub JL, Way SS, Nikolich-Žugich J, Kuhns MS (2018) A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice. PLoS ONE 13(6): e0198354. https://doi.org/10.1371/journal.pone.0198354 | en_US |
dc.identifier.issn | 1932-6203 | |
dc.identifier.pmid | 29864157 | |
dc.identifier.doi | 10.1371/journal.pone.0198354 | |
dc.identifier.uri | http://hdl.handle.net/10150/628376 | |
dc.description.abstract | T cell recognition of peptides presented within self-major histocompatibility complex (pMHC) molecules is essential for long-lived protective immunity. As mice age the number of naive CD4(+) and CD8(+) T cells declines. However, unlike for CD8(+) T cells, there are more naive and memory phenotype CD4(+) T cells that bind foreign pMHCII in old mice (18-22 months) than adults (12-15 weeks), suggesting increased promiscuity of pMHCII recognition with aging. Here we asked if CD4(+) T cell responses to immunization or infection increase with aging since the magnitude of a CD4(+) T cell response to a foreign pMHCII is proportional to the size of the precursor population in adult mice. We observed no difference in the number of pMHCII-specific CD4(+) T cells in adult versus old mice for pooled secondary lymphoid organs after immunization, bacterial infection, or viral infection, but we did observe diminished numbers of pMHCII-specific CD4(+) T cells in both the draining lymph node and brain of old mice after West Nile virus infection. These data indicate that an increased precursor frequency does not translate into more robust responses upon immunization or infection in old mice. | en_US |
dc.description.sponsorship | NIH/NIAID [HHSN272201100017C]; Pew Charitable Trusts; UACC/ALR Cytometry Core Facility; Cancer Center Support Grant [CCSG-CA 023074] | en_US |
dc.language.iso | en | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE | en_US |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0198354 | en_US |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0198354.g001 | en_US |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0198354.g002 | en_US |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0198354.g003 | en_US |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0198354.g004 | en_US |
dc.rights | © 2018 Deshpande et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice | en_US |
dc.type | Article | en_US |
dc.contributor.department | Univ Arizona, Coll Med, Dept Immunobiol | en_US |
dc.contributor.department | Univ Arizona, Coll Med, BIO Inst 5 | en_US |
dc.contributor.department | Univ Arizona, Coll Med, Arizona Ctr Aging | en_US |
dc.identifier.journal | PLOS ONE | en_US |
dc.description.note | Open access journal. | en_US |
dc.description.collectioninformation | This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu. | en_US |
dc.eprint.version | Final published version | en_US |
dc.source.journaltitle | PLOS ONE | |
dc.source.volume | 13 | |
dc.source.issue | 6 | |
dc.source.beginpage | e0198354 | |
refterms.dateFOA | 2018-08-09T18:00:08Z |