Abnormal language-related oscillatory responses in primary progressive aphasia
AffiliationUniv Arizona, Dept Speech Language & Hearing Sci
MetadataShow full item record
PublisherELSEVIER SCI LTD
CitationKielar, A., Deschamps, T., Jokel, R., & Meltzer, J. A. (2018). Abnormal language-related oscillatory responses in primary progressive aphasia. NeuroImage: Clinical, 18, 560-574. https://doi.org/10.1016/j.nicl.2018.02.028
Rights© 2018 The Authors. Published by Elsevier Inc.
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractPatients with Primary Progressive Aphasia (PPA) may react to linguistic stimuli differently than healthy controls, reflecting degeneration of language networks and engagement of compensatory mechanisms. We used magnetoencephalography (MEG) to evaluate oscillatory neural responses in sentence comprehension, in patients with PPA and age-matched controls. Participants viewed sentences containing semantically and syntactically anomalous words that evoke distinct oscillatory responses. For age-matched controls, semantic anomalies elicited left-lateralized 8-30 Hz power decreases distributed along ventral brain regions, whereas syntactic anomalies elicited bilateral power decreases in both ventral and dorsal regions. In comparison to controls, patients with PPA showed altered patterns of induced oscillations, characterized by delayed latencies and attenuated amplitude, which were correlated with linguistic impairment measured offline. The recruitment of right hemisphere temporo-parietal areas (also found in controls) was correlated with preserved semantic processing abilities, indicating that preserved neural activity in these regions was able to support successful semantic processing. In contrast, syntactic processing was more consistently impaired in PPA, regardless of neural activity patterns, suggesting that this domain of language is particularly vulnerable to the neuronal loss. In addition, we found that delayed peak latencies of oscillatory responses were associated with lower accuracy for detecting semantic anomalies, suggesting that language deficits observed in PPA may be linked to delayed or slowed information processing.
NoteOpen Access Journal.
VersionFinal published version
SponsorsOntario Brain Institute Ontario Neurodegenerative Disease Research Initiative (ONDRI); Alzheimer's Association New Investigator Research Grant; Ontario Research Coalition
- Functional reorganization of language networks for semantics and syntax in chronic stroke: Evidence from MEG.
- Authors: Kielar A, Deschamps T, Jokel R, Meltzer JA
- Issue date: 2016 Aug
- What role does the anterior temporal lobe play in sentence-level processing? Neural correlates of syntactic processing in semantic variant primary progressive aphasia.
- Authors: Wilson SM, DeMarco AT, Henry ML, Gesierich B, Babiak M, Mandelli ML, Miller BL, Gorno-Tempini ML
- Issue date: 2014 May
- Localization of electrophysiological responses to semantic and syntactic anomalies in language comprehension with MEG.
- Authors: Kielar A, Panamsky L, Links KA, Meltzer JA
- Issue date: 2015 Jan 15
- Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.
- Authors: Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS
- Issue date: 2017 Oct 1
- Adaptive significance of right hemisphere activation in aphasic language comprehension.
- Authors: Meltzer JA, Wagage S, Ryder J, Solomon B, Braun AR
- Issue date: 2013 Jun