Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities
Kiekens, Kelli C.
Syson, Nikolas C.
Barton, Jennifer K.
AffiliationUniv Arizona, Coll Opt Sci
Univ Arizona, Biomed Engn
MetadataShow full item record
PublisherSPIE-INT SOC OPTICAL ENGINEERING
CitationDavid Vega, Kelli C. Kiekens, Nikolas C. Syson, Gabriella Romano, Tressa Baker, Jennifer K. Barton, "Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities", Proc. SPIE 10470, Endoscopic Microscopy XIII, 104700M (14 February 2018); doi: 10.1117/12.2285059; https://doi.org/10.1117/12.2285059
JournalENDOSCOPIC MICROSCOPY XIII
Rights© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at firstname.lastname@example.org.
AbstractWhile Optical Coherence Microscopy (OCM), Multiphoton Microscopy (MPM), and narrowband imaging are powerful imaging techniques that can be used to detect cancer, each imaging technique has limitations when used by itself. Combining them into an endoscope to work in synergy can help achieve high sensitivity and specificity for diagnosis at the point of care. Such complex endoscopes have an elevated risk of failure, and performing proper modelling ensures functionality and minimizes risk. We present full 2D and 3D models of a multimodality optical micro-endoscope to provide real-time detection of carcinomas, called a salpingoscope. The models evaluate the endoscope illumination and light collection capabilities of various modalities. The design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet. A high NA optical path is designed to perform OCM and MPM while a low NA optical path is designed for the visible spectrum to navigate the endoscope to areas of interest and narrowband imaging. Different tests such as the reflectance profile of homogeneous epithelial tissue were performed to adjust the models properly. Light collection models for the different modalities were created and tested for efficiency. While it is challenging to evaluate the efficiency of multimodality endoscopes, the models ensure that the system is design for the expected light collection levels to provide detectable signal to work for the intended imaging.
VersionFinal published version
SponsorsNational Institutes of Health [NIH/NIBIB 1R01EB020605]; NSF [NSF-GRFP]