Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities
Author
Vega, DavidKiekens, Kelli C.
Syson, Nikolas C.
Romano, Gabriella
Baker, Tressa
Barton, Jennifer K.
Affiliation
Univ Arizona, Coll Opt SciUniv Arizona, Biomed Engn
Issue Date
2018
Metadata
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SPIE-INT SOC OPTICAL ENGINEERINGCitation
David Vega, Kelli C. Kiekens, Nikolas C. Syson, Gabriella Romano, Tressa Baker, Jennifer K. Barton, "Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities", Proc. SPIE 10470, Endoscopic Microscopy XIII, 104700M (14 February 2018); doi: 10.1117/12.2285059; https://doi.org/10.1117/12.2285059Journal
ENDOSCOPIC MICROSCOPY XIIIRights
© (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
While Optical Coherence Microscopy (OCM), Multiphoton Microscopy (MPM), and narrowband imaging are powerful imaging techniques that can be used to detect cancer, each imaging technique has limitations when used by itself. Combining them into an endoscope to work in synergy can help achieve high sensitivity and specificity for diagnosis at the point of care. Such complex endoscopes have an elevated risk of failure, and performing proper modelling ensures functionality and minimizes risk. We present full 2D and 3D models of a multimodality optical micro-endoscope to provide real-time detection of carcinomas, called a salpingoscope. The models evaluate the endoscope illumination and light collection capabilities of various modalities. The design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet. A high NA optical path is designed to perform OCM and MPM while a low NA optical path is designed for the visible spectrum to navigate the endoscope to areas of interest and narrowband imaging. Different tests such as the reflectance profile of homogeneous epithelial tissue were performed to adjust the models properly. Light collection models for the different modalities were created and tested for efficiency. While it is challenging to evaluate the efficiency of multimodality endoscopes, the models ensure that the system is design for the expected light collection levels to provide detectable signal to work for the intended imaging.ISSN
0277-786X1996-756X
Version
Final published versionSponsors
National Institutes of Health [NIH/NIBIB 1R01EB020605]; NSF [NSF-GRFP]ae974a485f413a2113503eed53cd6c53
10.1117/12.2285059