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    Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities

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    Author
    Vega, David
    Kiekens, Kelli C.
    Syson, Nikolas C.
    Romano, Gabriella
    Baker, Tressa
    Barton, Jennifer K.
    Affiliation
    Univ Arizona, Coll Opt Sci
    Univ Arizona, Biomed Engn
    Issue Date
    2018
    Keywords
    micro-endoscope
    optical design
    OCT
    OCM
    MPM
    multimodal endoscopy
    
    Metadata
    Show full item record
    Publisher
    SPIE-INT SOC OPTICAL ENGINEERING
    Citation
    David Vega, Kelli C. Kiekens, Nikolas C. Syson, Gabriella Romano, Tressa Baker, Jennifer K. Barton, "Full optical model of micro-endoscope with optical coherence microscopy, multiphoton microscopy and visible capabilities", Proc. SPIE 10470, Endoscopic Microscopy XIII, 104700M (14 February 2018); doi: 10.1117/12.2285059; https://doi.org/10.1117/12.2285059
    Journal
    ENDOSCOPIC MICROSCOPY XIII
    Rights
    © (2018) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).
    Collection Information
    This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.
    Abstract
    While Optical Coherence Microscopy (OCM), Multiphoton Microscopy (MPM), and narrowband imaging are powerful imaging techniques that can be used to detect cancer, each imaging technique has limitations when used by itself. Combining them into an endoscope to work in synergy can help achieve high sensitivity and specificity for diagnosis at the point of care. Such complex endoscopes have an elevated risk of failure, and performing proper modelling ensures functionality and minimizes risk. We present full 2D and 3D models of a multimodality optical micro-endoscope to provide real-time detection of carcinomas, called a salpingoscope. The models evaluate the endoscope illumination and light collection capabilities of various modalities. The design features two optical paths with different numerical apertures (NA) through a single lens system with a scanning optical fiber. The dual path is achieved using dichroic coatings embedded in a triplet. A high NA optical path is designed to perform OCM and MPM while a low NA optical path is designed for the visible spectrum to navigate the endoscope to areas of interest and narrowband imaging. Different tests such as the reflectance profile of homogeneous epithelial tissue were performed to adjust the models properly. Light collection models for the different modalities were created and tested for efficiency. While it is challenging to evaluate the efficiency of multimodality endoscopes, the models ensure that the system is design for the expected light collection levels to provide detectable signal to work for the intended imaging.
    ISSN
    0277-786X
    1996-756X
    DOI
    10.1117/12.2285059
    Version
    Final published version
    Sponsors
    National Institutes of Health [NIH/NIBIB 1R01EB020605]; NSF [NSF-GRFP]
    Additional Links
    https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10470/104700M/Full-optical-model-of-micro-endoscope-with-optical-coherence-microscopy/10.1117/12.2285059.full?SSO=1
    ae974a485f413a2113503eed53cd6c53
    10.1117/12.2285059
    Scopus Count
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    UA Faculty Publications

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