Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy
AffiliationUniv Arizona, Coll Med, Dept Immunobiol
Univ Arizona, Coll Med, Dept Med
Univ Arizona, Inst Bio5
MetadataShow full item record
PublisherPUBLIC LIBRARY SCIENCE
CitationBehrens NE, Wertheimer A, Klotz SA, Ahmad N (2018) Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy. PLoS ONE 13(6): e0199101. https://doi.org/10.1371/journal.pone.0199101
Rights© 2018 Behrens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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AbstractSeveral studies have shown an increased accumulation of terminally differentiated T cells during HIV infection, suggestive of exhaustion/senescence, causing dysregulation of T cell homeostasis and function and rapid HIV disease progression. We have investigated whether long-term antiretroviral therapy (ART), which controls viremia and restores CD4 T cell counts, is correlated with reduction in terminally differentiated T cells, improved ratios of na ve to memory and function of T cells in 100 virologically controlled HIV-infected patients. We show that while the median frequencies of terminally differentiated CD4(+) and CD8(+) T cells (CD28(-), CD27(-), CD57(+) and CD28-CD57(+)), were higher in the virologically controlled HIV-infected patients' cohort compared with uninfected individuals' cohort, the frequencies of these cells significantly decreased with increasing CD4 T cell counts in HIV-infected patients. Although, the naive CD4+ and CD8+ T cells were lower in HIV patients' cohort than uninfected cohort, there was a significant increase in both na ve CD4(+) and CD8(+) T cells with increasing CD4 T cell counts in HIV-infected patients. The underlying mechanism behind this increased naive CD4(+) and CD8(+) T cells in HIV-infected patients was due to an increase in recent thymic emigrants, CD4(+)CD31(+), as compared to CD4(+)CD31(-). The CD4+ T cells of HIV-infected patients produced cytokines, including IL-2, IL-10 and IFN-gamma comparable to uninfected individuals. In conclusion, virologically controlled HIV-infected patients on longterm ART show a significant reduction in terminally differentiated T cells, suggestive of decreased exhaustion/senescence, and improvement in the ratios of na ve to memory and function of T cells.
NoteOpen access journal.
VersionFinal published version
SponsorsArizona Biomedical Research Commission, Arizona Department of Health Services [ADHS14-082984]
Except where otherwise noted, this item's license is described as © 2018 Behrens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
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