Show simple item record

dc.contributor.authorBehrens, Nicole E.
dc.contributor.authorWertheimer, Anne
dc.contributor.authorKlotz, Stephen A.
dc.contributor.authorAhmad, Nafees
dc.date.accessioned2018-08-16T18:09:18Z
dc.date.available2018-08-16T18:09:18Z
dc.date.issued2018-06-13
dc.identifier.citationBehrens NE, Wertheimer A, Klotz SA, Ahmad N (2018) Reduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapy. PLoS ONE 13(6): e0199101. https://doi.org/10.1371/journal.pone.0199101en_US
dc.identifier.issn1932-6203
dc.identifier.pmid29897981
dc.identifier.doi10.1371/journal.pone.0199101
dc.identifier.urihttp://hdl.handle.net/10150/628559
dc.description.abstractSeveral studies have shown an increased accumulation of terminally differentiated T cells during HIV infection, suggestive of exhaustion/senescence, causing dysregulation of T cell homeostasis and function and rapid HIV disease progression. We have investigated whether long-term antiretroviral therapy (ART), which controls viremia and restores CD4 T cell counts, is correlated with reduction in terminally differentiated T cells, improved ratios of na ve to memory and function of T cells in 100 virologically controlled HIV-infected patients. We show that while the median frequencies of terminally differentiated CD4(+) and CD8(+) T cells (CD28(-), CD27(-), CD57(+) and CD28-CD57(+)), were higher in the virologically controlled HIV-infected patients' cohort compared with uninfected individuals' cohort, the frequencies of these cells significantly decreased with increasing CD4 T cell counts in HIV-infected patients. Although, the naive CD4+ and CD8+ T cells were lower in HIV patients' cohort than uninfected cohort, there was a significant increase in both na ve CD4(+) and CD8(+) T cells with increasing CD4 T cell counts in HIV-infected patients. The underlying mechanism behind this increased naive CD4(+) and CD8(+) T cells in HIV-infected patients was due to an increase in recent thymic emigrants, CD4(+)CD31(+), as compared to CD4(+)CD31(-). The CD4+ T cells of HIV-infected patients produced cytokines, including IL-2, IL-10 and IFN-gamma comparable to uninfected individuals. In conclusion, virologically controlled HIV-infected patients on longterm ART show a significant reduction in terminally differentiated T cells, suggestive of decreased exhaustion/senescence, and improvement in the ratios of na ve to memory and function of T cells.en_US
dc.description.sponsorshipArizona Biomedical Research Commission, Arizona Department of Health Services [ADHS14-082984]en_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g001en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g002en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g003en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g004en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g005en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g006en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.g007en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.t001en_US
dc.relation.urlhttp://dx.plos.org/10.1371/journal.pone.0199101.t002en_US
dc.rights© 2018 Behrens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleReduction in terminally differentiated T cells in virologically controlled HIV-infected aging patients on long-term antiretroviral therapyen_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Coll Med, Dept Immunobiolen_US
dc.contributor.departmentUniv Arizona, Coll Med, Dept Meden_US
dc.contributor.departmentUniv Arizona, Inst Bio5en_US
dc.identifier.journalPLOS ONEen_US
dc.description.noteOpen access journal.en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal published versionen_US
dc.source.journaltitlePLOS ONE
dc.source.volume13
dc.source.issue6
dc.source.beginpagee0199101
refterms.dateFOA2018-08-16T18:09:19Z


Files in this item

Thumbnail
Name:
journal.pone.0199101.pdf
Size:
98.60Mb
Format:
PDF
Description:
Final Published version

This item appears in the following Collection(s)

Show simple item record

© 2018 Behrens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as © 2018 Behrens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.