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Wide-field phase imaging for the endoscopic detection of dysplasia and early-stage esophageal cancer
Author
Fitzpatrick, Catherine R. M.Gordon, George S. D.
Sawyer, Travis W.
Bohndiek, Sarah E.
Wilkinson, Timothy D.
Affiliation
Univ Arizona, Coll Opt SciIssue Date
2018
Metadata
Show full item recordPublisher
SPIE-INT SOC OPTICAL ENGINEERINGCitation
C. R. M. Fitzpatrick, C. R. M. Fitzpatrick, G. S. D. Gordon, G. S. D. Gordon, T. W. Sawyer, T. W. Sawyer, T. D. Wilkinson, T. D. Wilkinson, S. E. Bohndiek, S. E. Bohndiek, } "Wide-field phase imaging for the endoscopic detection of dysplasia and early-stage esophageal cancer ", Proc. SPIE 10470, Endoscopic Microscopy XIII, 1047015 (28 February 2018); doi: 10.1117/12.2290910; https://doi.org/10.1117/12.2290910Journal
ENDOSCOPIC MICROSCOPY XIIIRights
© 2018 SPIE.Collection Information
This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.Abstract
Esophageal cancer has a 5-year survival rate below 20%, but can be curatively resected if it is detected early. At present, poor contrast for early lesions in white light imaging leads to a high miss rate in standard-of care endoscopic surveillance. Early lesions in the esophagus, referred to as dysplasia, are characterized by an abundance of abnormal cells with enlarged nuclei. This tissue has a different refractive index profile to healthy tissue, which results in different light scattering properties and provides a source of endogenous contrast that can be exploited for advanced endoscopic imaging. For example, point measurements of such contrast can be made with scattering spectroscopy, while optical coherence tomography generates volumetric data. However, both require specialist interpretation for diagnostic decision making. We propose combining wide-field phase imaging with existing white light endoscopy in order to provide enhanced contrast for dysplasia and early-stage cancer in an image format that is familiar to endoscopists. Wide-field phase imaging in endoscopy can be achieved using coherent illumination combined with phase retrieval algorithms. Here, we present the design and simulation of a benchtop phase imaging system that is compatible with capsule endoscopy. We have undertaken preliminary optical modelling of the phase imaging setup, including aberration correction simulations and an investigation into distinguishing between different tissue phantom scattering coefficients. As our approach is based on phase retrieval rather than interferometry, it is feasible to realize a device with low-cost components for future clinical implementation.ISSN
97815106142539781510614260
Version
Final published versionSponsors
Cancer Research UK Cambridge Cancer Centre Early Detection Programme [A20976]; CRUK [C11.303/A17197, C17594/A16267, C17594/A21102]; European Union's Seventh Framework Programme [FP7-PEOPLE-213-CIG-630729]ae974a485f413a2113503eed53cd6c53
10.1117/12.2290910