Elevated Aggression and Reduced White Matter Integrity in Mild Traumatic Brain Injury: A DTI Study
AuthorDailey, Natalie S.
Gottschlich, Melissa K.
Raikes, Adam C.
Satterfield, Brieann C.
Killgore, William D. S.
AffiliationUniv Arizona, Coll Med, Dept Psychiat
Keywordsmild traumatic brain injury
white matter integrity
diffusion tensor imaging
MetadataShow full item record
PublisherFRONTIERS MEDIA SA
CitationDailey NS, Smith R, Bajaj S, Alkozei A, Gottschlich MK, Raikes AC, Satterfield BC and Killgore WDS (2018) Elevated Aggression and Reduced White Matter Integrity in Mild Traumatic Brain Injury: A DTI Study. Front. Behav. Neurosci. 12:118. doi: 10.3389/fnbeh.2018.00118
Rights© 2018 Dailey, Smith, Bajaj, Alkozei, Gottschlich, Raikes, Satterfield and Killgore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Collection InformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at email@example.com.
AbstractMild traumatic brain injury (mTBI) remains the most commonly reported head injury in the United States, and is associated with a wide range of post-concussive symptoms including physical, cognitive and affective impairments. Elevated aggression has been documented in mTBI; however, the neural mechanisms associated with aggression at the chronic stage of recovery remain poorly understood. In the present study, we investigated the association between white matter integrity and aggression in mTBI using diffusion tensor imaging (DTI). Twenty-six age-matched adults participated in the study, including 16 healthy controls (HCs) and 10 individuals in the chronic stage of recovery (either 6-months or 12 months post-mTBI). Psychological measures of aggression included the Buss-Perry Aggression Questionnaire and the Personality Assessment Inventory (PAI). Axonal pathways implicated in affective processing were studied, including the corpus callosum, anterior thalamic radiation, cingulum and uncinate fasciculus, and measures of white matter integrity included fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). We found that adults with mTBI in the chronic stage of recovery had higher levels aggression. Individuals with mTBI also had greater RD in the corpus callosum compared to HCs, indicating reduced fiber integrity. Furthermore, we observed a significant association between reduced white matter integrity in the corpus callosum and greater aggression. Our findings provide additional evidence for underlying neuroanatomical mechanisms of aggression, although future research will be necessary to characterize the specific relationship between aggression and the white matter pathways we identified.
NoteOpen access journal.
VersionFinal published version
SponsorsOffice of the Assistant Secretary of Defense for Health Affairs; Defense Health Agency J9, Research and Development Directorate, through the US Army Medical Research and Materiel Command (USAMRMC) [W81XWH-12-0386]
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- Authors: Kraus MF, Susmaras T, Caughlin BP, Walker CJ, Sweeney JA, Little DM
- Issue date: 2007 Oct
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- Authors: Main KL, Soman S, Pestilli F, Furst A, Noda A, Hernandez B, Kong J, Cheng J, Fairchild JK, Taylor J, Yesavage J, Wesson Ashford J, Kraemer H, Adamson MM
- Issue date: 2017
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