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dc.contributor.authorDas, Lipsa
dc.contributor.authorGard, Jaime M.C.
dc.contributor.authorPrekeris, Rytis
dc.contributor.authorNagle, Raymond B.
dc.contributor.authorMorrissey, Colm
dc.contributor.authorKnudsen, Beatrice S.
dc.contributor.authorMiranti, Cindy K.
dc.contributor.authorCress, Anne E.
dc.date.accessioned2018-09-12T20:08:04Z
dc.date.available2018-09-12T20:08:04Z
dc.date.issued2018-08
dc.identifier.citationLipsa Das, Jaime M.C. Gard, Rytis Prekeris, et al. Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer. Mol Cancer Res August 1 2018 (16) (8) 1319-1331; DOI: 10.1158/1541-7786.MCR-17-0589en_US
dc.identifier.issn1541-7786
dc.identifier.issn1557-3125
dc.identifier.pmid29759989
dc.identifier.doi10.1158/1541-7786.MCR-17-0589
dc.identifier.urihttp://hdl.handle.net/10150/628679
dc.description.abstractThe laminin-binding integrins, alpha 3 beta 1 and alpha 6 beta 1, are needed for tumor metastasis and their surface expression is regulated by endocytic recycling. beta 1 integrins share the Rab11 recycling machinery, but the trafficking of alpha 3 beta 1 and alpha 6 beta 1 are distinct by an unknown mechanism. Using a mouse PDX tumor model containing human metastatic prostate cancer, Rab11 family interacting protein 5 (Rab11-FIP5) was identified as a lead candidate for a6b1 trafficking. Rab11-FIP5 and its membrane-binding domain were required for alpha 6 beta 1 recycling, without affecting the other laminin-binding integrin (i.e., alpha 6 beta 1) or unrelated membrane receptors like CD44, transferrin receptor, or E-cad-herin. Depletion of Rab11-FIP5 resulted in the intracellular accumulation of alpha 6 beta 1 in the Rab11 recycling compartment, loss of cell migration on laminin, and an unexpected loss of alpha 6 beta 1 recycling in cell-cell locations. Taken together, these data demonstrate that alpha 6 beta 1 is distinct from alpha 3 beta 1 via Rab11-FIP5 recycling and recycles in an unexpected cell-cell location.en_US
dc.description.sponsorshipPacific Northwest Prostate Cancer SPORE [P50CA97186]; PO1 NIH grant [PO1CA085859]; Richard M. LUCAS Foundation; Tim and Diane Bowden Cancer Biology Fellowship Award; NIH [NIDDKR01-DK064380]; [NIH-NCIRO1CA159406]; [NIH-NCIRO1CA154835]; [P30CA23074]en_US
dc.language.isoenen_US
dc.publisherAMER ASSOC CANCER RESEARCHen_US
dc.relation.urlhttp://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR-17-0589en_US
dc.rights©2018 American Association for Cancer Research.en_US
dc.titleNovel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Canceren_US
dc.typeArticleen_US
dc.contributor.departmentUniv Arizona, Canc Biol Grad Interdisciplinary Programen_US
dc.contributor.departmentUniv Arizona, Canc Ctren_US
dc.contributor.departmentUniv Arizona, Canc Ctr, Cellular & Mol Meden_US
dc.contributor.departmentUniv Arizona, Canc Ctr, Mol & Cellular Biolen_US
dc.identifier.journalMOLECULAR CANCER RESEARCHen_US
dc.description.note12 month embargo; published online: 14 May 2018en_US
dc.description.collectioninformationThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at repository@u.library.arizona.edu.en_US
dc.eprint.versionFinal accepted manuscripten_US
dc.source.journaltitleMolecular Cancer Research
dc.source.volume16
dc.source.issue8
dc.source.beginpage1319
dc.source.endpage1331


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