Older men display elevated levels of senescence-associated exercise-responsive CD28(null) angiogenic T cells compared with younger men
Simpson, Richard J.
AffiliationUniv Arizona, Dept Pediat, Dept Immunobiol, Dept Nutr Sci
MetadataShow full item record
CitationM. Ross, L. Ingram, G. Taylor, E. Malone, R. J. Simpson, D. West, G. Florida‐James. Older men display elevated levels of senescence‐associated exercise‐responsive CD28null angiogenic T cells compared with younger men. Physiol Rep, 6 (12), 2018, e13697, https://doi.org/10.14814/phy2.13697
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AbstractAging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31(+) T cells (angiogenic T cells; T-ANG) possess highly angiogenic capabilities; however, these cells are significantly reduced in older populations. In addition, older populations possess significantly higher senescent and highly differentiated T-cell levels in circulation, and these are reported to be highly exercise responsive. We investigated whether older adults display greater levels of circulating senescent (CD28(null)) T-ANG cells and whether these cells were more exercise responsive than CD28(+) T-ANG cells. Young (18-25years; n=9) and older (60-75years; n=10) healthy men undertook a 30-min cycling bout at 70% VO(2)peak, with circulating T-ANG cells (CD3(+)CD31(+)CD28(+/null); including CD4(+) and CD8(+) subsets) measured preexercise, postexercise, and 1h post exercise by flow cytometry. Older adults displayed reduced basal levels of T-ANG cells (mean +/- SEM: 410 +/- 81 vs. 784 +/- 118cells<bold>L</bold>, P=0.017), despite a greater proportion of these cells being CD28(null) (26.26 +/- 5.08 vs. 13.36 +/- 2.62%, P=0.044). Exercise significantly increased the circulating number of T-ANG cells in both young and older men. However, in older men alone, exercise preferentially mobilized CD28(null) CD8(+)T(ANG) cells compared with CD28(+) T-ANG cells (time x phenotype interaction: P=0.022; 74 +/- 29 vs. 27 +/- 15cells<bold>L</bold>, P=0.059), with no such difference observed between these phenotypes in the young population. In conclusion, this is the first study to demonstrate that despite observing lower circulating numbers of T-ANG cells, older adults display greater levels of senescent T-ANG cells in comparison with younger individuals, and these cells are more exercise responsive than CD28(+) T-ANG cells. Lower number of circulating T-ANG and greater levels of senescent-associated CD28(null) T-ANG may contribute to greater CVD risk with advancing age.
NoteOpen Access Journal.
VersionFinal published version
SponsorsEdinburgh Napier University
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